摘要
奥沙普秦主要用于风湿关节炎和肩周炎的治疗。由安息香与丁二酸酐在吡啶存在下反应得到中间产物4-氧-4-(2-氧-1,2-二苯基乙氧基)丁酸。以HAc为溶剂,再将4-氧-4-(2-氧-1,2-二苯基乙氧基)丁酸与HAc铵反应合成奥沙普秦,产率为75.9%。该合成方法操作简单,适合工业化生产。
Oxaprozin is mainly used for treatment of rheumatism arthritis and scapulohumeral periarthritis. In the presence of pyfidine, benzoin reacted with succinic anhydride to obtain the intermediate production 4-oxo-4- （2-oxo-1, 2-diphenylethox）butanoic acid. Oxaprozin was synthesized by the intermediate production 4-oxo-4- （2-oxo-1, 2-diphenylethox）butanoie acid reacting with ammonium acetate, in the presence of acetic acid. The reaction yield was 75.9%. The process is simple and suitable for industrial production.
出处
《化学工程师》
CAS
2015年第10期9-10,28,共3页
Chemical Engineer
基金
河南省科技厅基础与前沿项目(142300410104)
河南省高等教育教学改革项目(2014SJGLX319)
河南省教育厅自然科学项目(14A150056)
关键词
奥沙普秦
安息香
醋酸铵
丁二酸酐
合成
oxaprozin
benzoin
ammonium acetate
succinic anhydrie
synthesis
