摘要
背景神经病理性疼痛（neuropathicpain，NP）的形成机制非常复杂，其中免疫炎症对NP的产生和维持非常重要，小胶质细胞作为中枢神经系统（centralnervoussystem，CNS）的免疫活性细胞，已证实其激活与NP密切相关，而且其不同的极化状态（M1／M2）对CNS的免疫环境产生截然不同的损伤或保护作用。有研究发现，促进小胶质细胞M2型极化可抑制多种慢性神经炎性疾病，并在脊髓损伤（spinecordinjury，SCI）模型中产生镇痛作用。目的阐述小胶质细胞M2型极化与NP关系的研究进展。内容从NP的发病机制，小胶质细胞极化及与神经疾病关系，与NP发生、发展关系等研究进展展开综述。趋向从免疫炎症方面为NP的发病机制及其治疗提供新的思路。
Background The mechanisms of neuropathie pain （NP） are very complex, and immune inflammation plays an important role in generation and maintenance of NP. As the immune active cells of the central nervous system （CNS）, the status of microglia activation M1 and M2 have enormous different influences on whether protective or cytotoxic in the central nervous system immune environment. Recent studies have shown that promoting microglia towards M2 polarization can inhibit a variety of chronic neural inflammatory diseases and produce analgesic role in the spinal cord injury（SCI） model. Objective To describe the research advance regarding relationship of microglia M2 polarization with NP. Content This paper introduces the pathogenesis of NP, microglia polarization and its relationships with neurological disease, and the occurrence and development of NP. Trend To provide a new idea about the pathogenesis and treatment of NP from the immune inflammation aspect.
出处
《国际麻醉学与复苏杂志》
CAS
2015年第10期925-928,共4页
International Journal of Anesthesiology and Resuscitation
