摘要
目的比较小剂量米非司酮联合妈富隆与单用妈富隆治疗围绝经期功能失调性子宫出血的疗效。方法选择收治的围绝经期功能失调性子宫出血患者220例,随机分为观察组和对照组各110例。对照组患者给予妈富隆治疗;观察组患者给予小剂量米非司酮联合妈富隆治疗。对两组患者血清性激素(FSH、LH和E2)水平的变化、控制出血、完全止血时间以及临床疗效进行比较。结果治疗后观察组的FSH、LH及E2的浓度水平明显低于治疗前和对照组;治疗后观察组的控制出血时间及完全止血时间均短于对照组,具有显著性差异(P<0.05);治疗后观察组总有效率为97.5%,显著高于对照组的82.5%,差异有统计学意义(P<0.05)。结论小剂量米非司酮联合妈富隆在治疗围绝经期功能失调性子宫出血中,具有临床疗效显著,安全可靠等优点,可在临床推广应用。
Objective To compare the clinical efficacy of low dose Mifepristone combined with Marvelon and Marvelon alone for perimenopausal dysfunctional uterine bleeding.Methods 220 patients with perimenopausal dysfunctional uterine bleeding were randomly divided into observation group and control group.Control group was given Marvelon,while observation group was given low dose Mifepristone combined with Marvelon.The levels of serum sex hormones,including FSH,LH and E2 were recorded.The time to control of the bleeding,complete stop of bleeding and clinical efficacy of patients in two groups were compared.Results The levels of FSH,LH and E2 of patients in observation group after treatment were significantly lower than that before treatment and control group（P〈0.05）.The time to control of the bleeding and complete stop of bleeding of patients in observation group was significantly shorter than those in control group（P〈0.05）.Total efficiency of patients in observation group（100%）was significantly higher than that in control group（82.5%）（P〈0.05）.Conclusion Low dose Mifepristone combined with Marvelon in treatment of perimenopausal dysfunctional uterine bleeding is effective,safe,reliable and worthy of clinical application.
出处
《西部医学》
2015年第10期1479-1480,1484,共3页
Medical Journal of West China
基金
国家自然科学基金(81000240)
