摘要
目的探讨硅胶密封碘-125（I125）放射性支架与钛合金密封I125放射性支架进行同质对比研究的可行性。方法采用浸涂法将医用硅胶溶液与放射性I125溶液混合，涂抹在不可降解的胰胆管支架特定位置上，投入的I125溶液总活度为24mCi，制成20个硅胶密封I125放射性支架，并收集相同总活度的20个传统钛合金密封I125放射性支架，比较这2种不同制作工艺的放射性I125支架的放射性核素利用率。结果在投入放射性I125溶液总量相同的情况下，20个硅胶密封的I125放射性支架核素的利用率为91．2％（21878／24000），20个钛合金密封的I125放射性支架核素的利用率为50．1％（12031／24000），硅胶密封I125放射性支架的核素利用率明显要高于钛合金密封I125的放射性支架（P〈0．05）。结论采用医用硅胶密封I125溶液制成的放射性支架具有很高的核素利用率，且节约了成本和能源，可进一步研究。
Objective To develop a new silicone coating iodine-125（s-125I） radioactive stent, and to compare it with the traditional titanium coating iodine-125 （t2zsI） radioactive stent. Methods Medical silicone solution was mixed with 125I solution, evenly applied to specific locations of stents to make the sili- cone-coated 125I stents. The total radioactivity of 125I solution was 24mCi, by which 20 silicone-coated 125I stents were made. A total of 20 traditional titanium stents of the same radioactivity were collected, and the u- tilization rate of the radionuclides of the two types of stents were compared. Results With the same amount of radioactivity, the s225 1 stent showed a higher utilization rate of nuclide [ 91.2% （21 878/24 000 ） VS 50. 1% （ 12 031/24 000） ] （P 〈 0. 05 ）. Conclusion The s-125I stent has a high utilization rate of nuclide, which can save the cost and energy largely. However, the application of the s-125I stent still needs further research.
出处
《中华消化内镜杂志》
北大核心
2015年第10期678-681,共4页
Chinese Journal of Digestive Endoscopy
关键词
胆管肿瘤
碘-125
硅胶
支架
Bile duct neoplasms
Iodine-125
Silica gel
Stents
