摘要
恶性气道狭窄是由各种恶性肿瘤引起呼吸困难甚至窒息的危急重症,多数患者确诊时已处于肿瘤晚期而失去手术机会。目前姑息性治疗主要是气道支架置入术,可缓解患者气道狭窄症状,但因其对肿瘤无任何治疗作用,随着生存期的延长,气道支架再狭窄情况越益突出,远期疗效受到严重影响。近期我国学者将具有抗肿瘤作用的放射性^125I粒子安置在气道支架上治疗恶性气道狭窄,可显著降低气道再狭窄概率,且患者生存期得到延长,但仍然面临一些问题需要攻克。本文就放射性^125I粒子支架的基本情况及其在恶性气道狭窄病变中的临床应用现状作一综述。
Malignant airway stenosis is a critical and severe disease resulted from various malignant tumors that cause dyspnea or even suffocation.Most patients have already been in the late stage of the tumor when the diagnosis is confirmed and have lost the chance of surgery.At present,airway stent placement is the main palliative treatment,which can relieve the symptoms of airway stenosis.However,as stent placement has no therapeutic effect on the tumor,with the prolongation of survival,the restenosis of the airway stent will become more and more prominent,and the long-term efficacy will be seriously affected.Recently,Chinese scholars have developed a kind of airway stent carrying^125Ⅰseeds that have anti-tumor effect,which is employed for the treatment of malignant airway stenosis.The implantation of such stents can significantly reduce the probability of airway restenosis and prolong the survival time of patients.But in clinical practice there are still some problems which are badly in need to be resolved.This paper reviews the basic features of stents carrying radioactive^125Ⅰseeds and their clinical applications in treating malignant airway stenosis.
作者
林珑
高宝安
LIN Long;GAO Baoan(Department of Respiratory and Critical Care Medicine,Yichang Municipal Central People’s Hospital,First Clinical Medical College of Three Gorges University,Yichang,Hubei Province 443003,China)
出处
《介入放射学杂志》
CSCD
北大核心
2020年第3期328-331,共4页
Journal of Interventional Radiology
