摘要
目的分析传统实验室检测指标对酒精性肝病(alcoholic liver disease,ALD)的诊断价值。方法男性肝病患者63例,其中非酒精性肝病(non-alcoholic liver disease,NALD)35例(NALD组),ALD患者28例(ALD组);同期体检健康者28例为对照组。比较3组患者血清γ-谷氨酰转移酶(gamma-glutamyl transferase,GGT)、纤维结合蛋白(fibronectin,Fn)、谷草转氨酶(glutamic-oxaloacetic transaminase,GOT)水平,观察ALD组治疗前、后3项指标的变化,评估Fn、GGT及GOT对ALD的诊断价值。结果治疗前ALD组和NALD组患者血清GGT[(67.5±54.4)、(69.8±49.6)u/L)]、Fn[(335.6±59.5)、(354.0±62.1)mg/L]及GOT[(19.3±10.3)、(10.4±7.3)u/L)]均高于对照组[(18.5±8.3)u/L、(207.4±21.3)mg/L、(7.0±4.5)u/L)](P<0.05),ALD组血清GOT水平高于NALD组(P<0.05);治疗后ALD组血清Fn[(277.0±71.3)mg/L]和GOT[(7.4±5.3)u/L]较治疗前下降(P<0.05),GGT[(62.7±53.6)u/L]与治疗前比较差异无统计学意义(P>0.05);ALD组GOT阳性率(75.0%)高于NALD组(45.7%)(P<0.05),Fn、GGT阳性率(57.1%、89.3%)与NALD组(60.0%、88.6%)比较差异无统计学意义(P>0.05)。结论 GGT、GOT及Fn可用于ALD患者的诊断和鉴别诊断,GGT诊断ALD的敏感性高,GOT和Fn对评价ALD患者药物疗效有一定价值。
Objective To analyze the value of detection of traditional laboratory test indexes to the diagnosis of alcoholic liver disease （ALD）. Methods In 63 male patients with liver disease, there were 35 patients with non-ALD （NALD） （NALD group） and 28 with ALD （ALD group）. Another 28 healthy volunteers were as controls （control group）. The changes of gamma-glutamyl transferase （GGT）, fibronectin （Fn） and glutamic-oxaloacetic transaminase （GOT） levels were compared before and after treatment among three groups to evaluate the values of GGT, Fn and GOT to the diagnosis of ALD. Results Before treatment, the levels of GGT （（67.5±54.4）, （69.8±49.6） u/L）, Fn （（335. 6± 59.5）, （354.0±62. 1） mg/L） and GOT （（19.3±10. 3）, （10. 4±7. 3） u/L） in ALD group and NALD group were higher than those in control group （（18.5±8.3） u/L, （207. 4±21. 3） mg/L, （7.0±4.5） u/L） （P〈0.05）, and GOT level was higher in ALD group than that in NALD group （P〈0.05）. The levels of Fn （（277.0±71.3） mg/L） and GOT （（7.4±5.3） u/L） were lower after treatment than those before treatment in ALD group （P〈0.05）, and GGT level showed no significant difference after treatment （（62. 7 ± 53. 6） u/L） （P〉0.05）. The positive rate of GOT in ALD group （75.0%） was higher than that in NALD group （45. 7%） （P〈0.05）. There was no significant difference in the positive rates of Fn and GGT between ALD group （57.1%, 89.3%） and NALD group （60.0%, 88.6%） （P〉0.05）. Conclusion GGT, GOT and Fn can be used for the diagnosis and differential diagnosis of ALD. GGT has a high sensitivity for the diagnosis of ALD, while GOT and Fn have values to the evaluation of drug efficacy on ALD.
出处
《中华实用诊断与治疗杂志》
2015年第10期997-998,1001,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
国家临床重点专科建设项目(2013年)
河南省科技攻关项目(201303120)
关键词
酒精性肝病
药物治疗
Γ-谷氨酰转移酶
纤维结合蛋白
谷草转氨酶
Alcoholic liver disease
non-alcoholic liver disease
gamma-glutamyl transferase
fibronectin
glutamic- oxaloacetic transaminase
