摘要
目的探讨血清丙氨酸氨基转移酶(ALT)与冠心病(CHD)的关系。方法选择2011年在天津医科大学第二医院心脏科住院的426例患者,均检测血清ALT水平,并行冠状动脉造影评价冠状动脉病变程度。根据冠状动脉造影结果分为冠心病组(294例)和对照组(132例)。冠心病组再根据病变支数分为单支病变组(89例)、双支病变组(91例)和多支病变组(114例);分析血清ALT水平与冠状动脉病变严重程度的相关性。结果冠心病组血清ALT水平明显高于对照组,差异有统计学意义〔(23.4±18.7)U/L和(17.8±13.2)U/L,P<0.01〕;冠心病3个亚组及对照组ALT水平间差异有统计学意义(F=5.137,P=0.002),其中多支病变组与对照组、单支病变组、双支病变组比较差异均有统计学意义(q=5.54,P=0.00;q=2.85,P=0.04;q=3.00,P=0.03),其他各组组间两两比较,差异均无统计学意义(P>0.05)。Logistic多因素回归分析显示,高血清ALT水平是冠心病的危险因素〔OR=0.966,95%CI(0.944,0.988),P<0.01〕。结论冠心病患者血清ALT水平明显高于非冠心病患者,高血清ALT水平是反映冠心病严重程度的指标,具有独立预测价值。
Objective To study the relationship between the serum alanine aminotransferase(ALT) level and coronary heart disease(CHD).Methods A total of 426 inpatients from the Second Hospital of Tianjin Medical University in 2011 were enrolled in this study and their serum ALT levels were determined and the coronary artery angiography was performed.Based on the results of coronary artery angiography,these patients were divided in the CHD group(n=294) and control group(n=132).The CHD group was further divided into three subgroups:single-branch subgroup(n=89),double-branch subgroup(n=91),and multiple-branch subgroup(n=114).The levels of serum ALT were compared among these groups.Results The serum ALT level was significantly higher in the CHD group than in the control group((23.4±18.7)U/L vs.(17.8±13.2)U/L,P<0.01).The three subgroups also showed significantly different ALT level when compared with the control group(F=5.137,P=0.002).Multivariate Logistic regression analysis showed the higher serum ALT level was associated with the occurrence of CHD(OR=0.966,95%CI(0.944,0.988),P<0.01).Conclusion CHD patients have higher serum ALT level than non-CHD patients.Serum ALT level can be used for predicting the severity of CHD.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第8期888-890,共3页
Chinese General Practice
