摘要
目的 探讨白虎加人参汤联合复方薤白胶囊对重症肺炎痰热腑实证患者的临床疗效.方法 采用前瞻性研究方法,选择2012年1月至2013年12月江苏大学附属昆山市第一人民医院呼吸科病房收治的266例痰热腑实型重症肺炎患者,按简单随机方法分为中西医结合治疗组136例和西医治疗对照组130例.两组均根据病情给予西医基础治疗;中西医结合组在西医治疗的基础上加用白虎加人参汤联合复方薤白胶囊350 mg,每日3次,每次4粒（每粒350 mg）,7 d为1个疗程.比较两组患者体温下降速度、中医症状改善程度、外周血白细胞计数（WBC）、中性粒细胞比例及内源性致热原产生的情况.结果 两组治疗后体温、中医症状积分、WBC、中性粒细胞比例均较治疗前降低,均于治疗后3 d达谷值,且以中西医结合治疗组降低更显著〔体温（℃）：36.5±0.0比37.0±0.0,中医症状积分（分）：1.7±0.2比6.1±0.7,WBC（×10^9/L）：7.1±0.3比8.3±0.5,中性粒细胞比例：0.64±0.02比0.76±0.23,均P〈0.05〕.以西医治疗对照组治疗后白细胞介素-1β（IL-1β）、 肿瘤坏死因子-α（TNF-α）、干扰素（IFN-α、IFN-γ）、白细胞介素-6（IL-6）水平为1,中西医结合治疗组治疗后6 h IL-1β、TNF-α、IFN-α、IFN-γ、IL-6均较西医治疗对照组明显下降,12 h到达谷值〔IL-1β、TNF-α、IFN-α、IFN-γ、IL-6与西医治疗对照组的相对表达量分别为0.37、0.16、0.21、0.27、0.15〕,24 h又有轻度回升.结论 加用白虎加人参汤联合用复方薤白胶囊治疗痰热腑实型重症肺炎患者具有良好的疗效.
Objective To study the effects of Baihu Rensen decoction combined with Fufang Xiebai capsules for treatment of patients with severe pneumonia accompanied by heat-phlegm and sthenic-fu syndrome.Methods A prospective study was conducted; 266 severe pneumonia cases with heat-phlegm and sthenic-fu syndrome admitted into the Department of Respiratory Diseases in Kunshan Hospital Affiliated to Jiangsu University from January 2012 to December 2013 were selected. The patients were randomly divided into a integrated traditional Chinese and western medicine group （136 cases） and a western medicine treatment group （130 cases）. Both groups were given basic conventional western medicine according to the disease situation. The integrated traditional Chinese medicine （TCM） was additionally given Baihu Rensen decoction combined with 350 mg of Fufang Xiebai capsules, 3 times a day, 4 grain each time, 7 days constituting a course of treatment. The rate of body temperature descent, the degree of improvement in clinical TCM symptoms, peripheral white blood cell （WBC） count, neutrophil percentage and the situation of endogenous pyrogen production in the two groups were compared.Results After treatment, the body temperature, TCM symptom scores, WBC count and neutrophil percentage were lower than those before treatment, 3 days after treatment these data reached their valley values, and the decrease in level was more significant in the combination group [body temperature （℃）： 36.5±0.0 vs. 37.0±0.0, TCM symptom scores： 1.7±0.2 vs. 6.1±0.7, WBC （×10^9/L）： 7.1±0.3 vs. 8.3±0.5, neutrophil percentage： 0.64±0.02 vs. 0.76±0.23, allP 〈 0.05]. Interleukin-1β （IL-1β）, tumor necrosis factor-α （TNF-α）, interferon （IFN-α, IFN-γ）, and interleukin-6 （IL-6） level in western medicine （WM） group was respectively marked 1, the levels of IL-1β, TNF-α, IFN-α, IFN-γ, and IL-6 in combination group after treatment for 6 hours were significantly lower than those of WM group, and reached
出处
《中国中西医结合急救杂志》
CAS
北大核心
2015年第5期467-471,共5页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
江苏省卫生厅科技项目（YD201403）
江苏省苏州市科技发展项目（SYSD2013162）
关键词
肺炎
重症
痰热腑实证
白虎加人参汤
复方薤白胶囊
Severe pneumonia
Heat-phlegm and sthenic-fu syndrome
Baihu Rensen decoction
Fufang Xiebai capsules
