摘要
目的分析欣母沛预防剖宫产产妇产后出血的临床效果。方法选取2013年11月至2014年11月于我院产科分娩并接受剖宫产的300例产妇作为研究对象,按照随机数字表法将其分为对照组与观察组两组,每组分别150例。对照组在剖宫产胎儿娩出后,肌注缩宫素,肛塞米索前列醇,作产后出血预防处理。观察组则在此基础上加用欣母沛预防产后出血,记录两组产妇术中及产后不同时间段尿量与出血量,并统计两组产妇不良反应发生率。结果观察组产妇术中、产后2 h及24 h尿量分别为(68.89±13.60)ml、(187.42±29.61)ml、(1415.21±268.15)ml,其术中及产后不同时间段尿量均多于对照组(P<0.05);观察组产妇术中、产后2h及24h出血量分别为(353.31±45.95)ml、(129.06±28.53)ml、(464.98±102.12)ml,其术中及产后不同时间段出血量均明显少于对照组(P<0.05);观察组产妇发生恶心15例,呕吐16例,整体不良反应发生率为20.67%,但患者肠胃不适症状无需特殊处理,症状伴随血药浓度的下降而消失,其不良反应发生率与对照组相比差异无统计学意义(P>0.05)。结论在剖宫产产妇产后出血预防中应用欣母沛方案,对产后出血预防效果好,起效时间快,疗效确切,但由于欣母沛价格相对昂贵,一般仅提倡在部分合并高危因素剖宫产产妇产后出血预防中应用。
Objective To analyze the clinical effect that Hemabate has on maternal postpartum hemorrhage of cesarean section. Methods 300 cases of pregnant women who received cesarean delivery in obstetrical department of our hospital from November 2013 to November 2014 were selected as the research object and randomly divided into control group and observation group accordingto random number table. There were 150 cases in each group. The women in control group received intramuscular injection of oxytocin and anal plug misoprostol as the treatment for postpartum hemorrhage after cesarean section. Based on the control group,the observation group received Hemabate to prevent postpartum hemorrhage. The urine volume and the amount of bleeding of two groups were recorded during cesarean section and in different period of time after delivery. And the rates of adverse reactions of the two groups were counted. Results The urine volume of observation group during cesarean section and postpartum 2h and 24 h were（ 68. 89 ± 13. 60） ml,（ 187. 42 ± 29. 61） ml and（ 1415. 21 ± 268. 15） ml which were more than those of the control group（ P〈0. 05）. The amount of bleeding of observation group during cesarean section and 2h,24 h after delivery were（ 353. 31 ± 45. 95） ml,（ 129. 06 ± 28.53） ml and（ 464. 98 ± 102. 12） ml which were significantly less than the control group（ P〈0. 05）. There were15 cases of nausea and 16 cases of vomiting in the observe group. The overall incidence of adverse reactions was20. 67%. However, patients with gastrointestinal symptoms didn ＇t need special treatment since symptoms disappeared with the decrease of blood concentration. The difference of occurrence rate of adverse reactions was not statistically significant between the two groups（ P〈0. 05）. Conclusions The application of Hemabate in the prevention of postpartum hemorrhage of cesarean section receives good effect and works fast and the curative effect is exact. Because of the relatively high price of Hemabate,i
出处
《齐齐哈尔医学院学报》
2015年第25期3796-3798,共3页
Journal of Qiqihar Medical University
关键词
产后出血
欣母沛
预防
剖宫产
Postpartum hemorrhage
Hemabate
Prevention
Cesarean section
