摘要
目的:探讨卵巢肿瘤彩超血流指标阻力指数(RI)与卵巢组织中微血管密度(MVD)及促血管生成素-2(Ang-2)的相关性。方法:经手术病理证实的55例卵巢肿瘤患者,术前应用彩色多普勒超声观察卵巢肿瘤内部血流并测定RI值,术后对所切除卵巢肿瘤组织标本分别采用免疫组化法检测其组织中MVD及Ang-2表达,分析RI与MVD、Ang-2的相关性及与肿瘤性质分级之间的相关性。结果:卵巢肿瘤的良恶性与RI呈负相关(r=-0.577,P<0.05);MVD各组间呈正相关(r=0.750,P<0.01);RI与MVD呈显著负相关(r=-0.537,P<0.05);Ang-2与肿瘤分级呈显著正相关(r=0.573,P<0.05)。结论 :RI、MVD及Ang-2分别从不同角度反映了卵巢肿瘤中新生血管的形成,Ang-2有望作为卵巢癌的临床诊断指标之一,三者联合应用可对术前术后卵巢肿瘤的血管形成进行综合评价,为卵巢癌的抗血管新生治疗及预后评估提供有价值信息,具有较重要的临床预测价值。
Objective： To evaluate the correlation between intratumoral blood flow index of resistance index （RI）, assessed by color Doppler and microvascular density（MVD）, together with expression of angiopoietin-2（Ang-2） in ovarian tumor. Meth- ods： For 55 patients with ovarian tumor proved by pathologic histology examination, CDFI was performed preoperatively to de- tect the arterial blood flow signals, and the lowest RI values were recorded. MVD and the expression of Ang-2 were exam- ined by immunohistochemical assay. Results： There was a significant negative correlation with RI for benign and malignant o- varian tumors （r=-0.577, P〈0.05）. With the increase of tumor grade, MVD showed a significantly positive correlation （r=0.750, P〈0.01）. There was a negative correlation between RI value and MVD（r=-0.537, P〈0.05）. Ang-2 and tumor grade were signif- icantly positively correlated（r=0.573, P〈0.05）. Conclusions： Ang-2 is expeeted to be one of the indicators of clinical diagnosis of ovarian cancer. Combined application of RI, MVD and Ang-2 can comprehensively evaluate the angiogenesis of ovarian tu- mors before and after operation, which could be helpful in forecasting prognosis and therapy of ovarian cancer.
出处
《中国临床医学影像杂志》
CAS
北大核心
2015年第10期728-731,共4页
Journal of China Clinic Medical Imaging
基金
山西省太原市科技项目(12016906)
