摘要
目的探讨益生菌肠内营养治疗重症急性胰腺炎(SAP)的临床效果。方法将2013年7月至2014年12月福建省立医院收治的96例SAP患者分为益生菌肠内营养组(观察组)和常规治疗组(对照组),每组48例。比较两组患者住院天数、腹痛消失时间、CRP恢复时间、血淀粉酶恢复时间、感染率、并发症发生率以及肠内菌群变化情况。结果治疗后观察组与对照组比较,患者平均住院天数、腹痛消失时间、CRP恢复时间及血淀粉酶恢复时间均缩短(P<0.05),且感染发生率及并发症的发生率均降低,差异有统计学意义(P<0.05)。观察组患者肠道双歧杆菌、乳杆菌的总数较治疗前显著提高(P<0.05)。结论早期应用益生菌辅助治疗SAP可有效调节肠道菌群微生态平衡,降低SAP肠黏膜损伤,保护肠屏障功能,进而改善其病程及预后。
Objective To investigate the clinical effect of enteral probiotics in the treatment of severe acute pancreatitis （SAP）. Methods A total of 96 patients with SAP admitted in our hospital from July 2013 to December 2014 were randomly divided into Enteral probiotics group （the observation group） and Conven- tional therapy group （the control group） respectively, 48 cases in each group. The hospital stay, time to disappearance of abdominal pain, time to recovery of CRP, time to recovery of serum amylase, infection rate, complication rate and changes of intestinal flora were compared between the two groups. Results Af- ter treatment, the time to disappearnce of abdominal pain, time to recovery of CRP, time to recovery of ser- um amylase as well as the average hospitalization days in the observation group were shorter than those in the control group （P〈0.05）. The incidence rates of infections and complications in both groups decreased significantly （P〈0.05）. The amount of intestinal bifidobacteria and lactobacilli in the observation group im- proved significantly after the treatment （P〈0.05）. Conclusion Early application of probioties as adjuvant therapy of SAP can effectively regulate micro-ecological balance of intestinal flora, reduce intestinal mucosal damage, protect the intestinal barrier function, and improve clinical course and prognosis of SAP.
出处
《中国微生态学杂志》
CAS
CSCD
2015年第10期1170-1173,共4页
Chinese Journal of Microecology
关键词
重症急性胰腺炎
益生菌
治疗效果
Severe acute pancreatitis
Probiotics
Treatment effect
