摘要
目的:探讨肠内营养混悬液(SP)早期营养支持对重症急性胰腺炎的影响。方法:选取2014年10月—2017年10月黄冈市中心医院收治的重症急性胰腺炎患者80例作为研究对象,以随机数字表法分为观察组和对照组,每组40例。对照组患者给予肠外营养支持,观察组患者给予肠内营养混悬液(SP)进行早期营养支持。对比观察两组患者的免疫功能改善、肠黏膜屏障功能恢复及并发症发生情况。结果:治疗后,观察组患者CD4^+、CD4^+/CD8^+、免疫球蛋白M及免疫球蛋白G水平明显优于对照组,差异均有统计学意义(P<0.05);治疗后,观察组患者血淀粉酶、降钙素原、血脂肪酶及D-乳酸水平明显优于对照组,差异均有统计学意义(P<0.05);观察组患者并发症发生率为2.5%(1/40),明显低于对照组的17.50%(7/40),差异有统计学意义(P<0.05)。结论:肠内营养混悬液(SP)早期营养支持用于重症急性胰腺炎,可有效改善患者的免疫功能与肠黏膜屏障功能,减少并发症的发生,预后较好。
OBJECTIVE： To probe into the effects of early nutritional support of enteral nutrition suspension （SP） on severe acute pancreatitis. METHODS： 80 patients with severe acute pancreatitis admitted into Huanggang Central Hospital from Oct. 2014 to Oct. 2017 were selected and divided into observation group and control group via random number table, with 40 cases in each group. The control group was treated with parenteral nutritional support, while the observation group was enteral given early nutritional support of enteral nutritional suspension （SP）. Differences in improvements of immunologic function, recovery of intestinal mucosal barrier function and incidences of complications between two groups were compared and observed. RESULTS： After treatment, the CD4＋, CD4＋/CD8＋, immunoglobulin M and immunoglobuhn G of observation group were significantly better than those of the control group, with statistically significant differences （P 〈 0. 05 ）; after treatment, levels of blood amylase, procalcitonin, blood lipase and D-lactic acid of observation group were significant better than those of the control group, with statistically significant differences （P 〈 0. 05） ; the incidence of complications of observation group was 2. 5% （ 1/40）, which was significantly lower than that of the control group （17. 50%, 7/40）, with statistically significant difference （P 〈 0. 05）. CONCLUSIONS： Early nutritional support of enteral nutritional suspension（SP） in treatment of severe acute pancreatitis can effectively improve patients＇ immunologic function and intestinal mucosal barrier function, with less complications and better prognoses.
作者
方亮
陈颖
陈会
吴继雄
FANG Liang;CHEN Ying;CHEN Hui;WU Jixiong(Dept. of Gastroenterology, Huanggang Central Hospital, Hubei Huanggang 438000, Chin)
出处
《中国医院用药评价与分析》
2018年第4期481-482,485,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
