摘要
目的：分析带状疱疹后神经痛（post herpetic neuralgia,PHN）患者与对照者脑电功率与频率的差异,探讨神经病理性疼痛的发生机制.方法：对PHN患者与对照者进行视觉模拟疼痛评分（visual analogue scale,VAS）、Beck焦虑量表、Beck抑郁量表,记录闭目状态128导脑电图20 min.采用傅里叶变换计算功率谱及功率峰值、频率峰值.结果：①两组间焦虑抑郁状态患病人数无显著性差异.②病例组功率峰值较对照组增高（P＜0.01）;7～13Hz功率在双侧额、中央、顶、枕区均增高（P＜0.05）;功率峰值与VAS呈线性正相关,Pearson相关系数为0.58 （P＜0.05）.③病例组频率峰值较对照组有降低趋势.结论：PHN患者存在脑的广泛激活,而且激活程度与疼痛程度呈正相关.PHN患者频率峰值有降低趋势,可能与异常的丘脑皮层节律有关.
Objective：To analyze electroencephalogram （EEG） power and frequency difference between post herpetic neuralgia （PHN） patients and healthy controls,aiming to investigate the neuronetwork mechanism of neuropathic pain.Methods：Both PHN patients and controls were examined with visual analogue scale （VAS）,Beck Anxiety Inventory （BAI）,Beck Depression Inventory （BDI） and recorded with 128-channel EEG under eye-closed state for 20 min.EEG power spectrum,as well as peak power and peak frequency,was calculated by the method of fast Fourier transform.Results：① There was no significant difference in the prevalence of anxiety and depression between PHN patients and controls.② PHN patients showed elevated peak power （P ＜ 0.01）.The increased electrical power within 7 ～ 13 Hz were diffusely located in bilateral frontal,temporal,parietal and occipital regions （P ＜ 0.05）.The peak power in PHN patients had positive correlation with the VAS （Pearson correlation coefficient 0.58,P ＜ 0.05）.③ PHN patients showed a trend of decrease in peak frequency compared with controls.Conclusions：PHN patients show wide activation of the brain regions,and the activation degree positively correlates with the pain severity.Peak frequency of PHN patients shows a trend of decrease,which may associate with thalamocortical dysrhythmia.
出处
《中国疼痛医学杂志》
CAS
CSCD
2015年第9期668-673,共6页
Chinese Journal of Pain Medicine
基金
国家自然科学基金项目(81230023)
关键词
带状疱疹后神经痛
脑电图
EEG
功率谱
Post herpetic neuralgia
Electroencephalogram
EEG
Power spectrum.
