摘要
目的:观察加巴喷丁治疗带状疱疹后神经痛的有效性和安全性。方法:带状疱疹后神经痛病人77例随机分为加巴喷丁组37例和布洛芬组40例,两组病人分别使用加巴喷丁胶囊1 800 mg.d-1或布洛芬胶囊600 mg.d-1,总共接受4周的药物治疗。以疼痛缓解程度作为评价疗效的指标,并对治疗过程中出现的不良反应进行评估。结果:治疗后加巴喷丁组视觉模拟疼痛评分(VAS)2.28±0.96,布洛芬组VAS为3.49±1.45,两组间VAS比较,差异有统计学意义(P<0.01)。加巴喷丁有较好的耐受性,不良反应主要表现为头晕、头昏、嗜睡和转氨酶升高等。结论:加巴喷丁可明显降低带状疱疹后神经痛的程度,并有较好的耐受性。
Objective： To investigate the effectiveness and safety of gabapentin in the treatment of postherpefie neuralgia（PHN）.Methods： A total of 77 patients with PHN were randomly divided into control group who received ibuprofen therapy（n=37） and treatment group who received gabapentin therapy（n=40）.The quantification of severity of pain was done using visual analogue scale（VAS） after 4 weeks.Adverse reactions were also observed.Results： The average VAS score was 2.28±0.96 in the treatment group and 3.49±1.45 in the control group with a significant difference between the two groups（P0.01）.Gabapentin was well tolerated,and the most common adverse events were dizziness,vertigo,somnolence and transient abnormality of hepatic function.Conclusion： Gabapentin provides significant pain relief in patients of PHN,with very little incidence of adverse reactions.
出处
《现代医学》
2012年第2期196-198,共3页
Modern Medical Journal
