摘要
糖尿病心肌病(DCM)是一种以心肌结构和功能重构为特征的特异性心肌病,其发生不依赖于冠心病、高血压和其他心脏疾病。影响糖尿病心肌病的因素很多,如代谢紊乱、微血管病变、钙转运缺陷及自主神经病变等因素,但其发病机制尚不清楚。微小RNA(miRNAs)是一种转录后调节基因表达的非编码小RNA,参与调节糖尿病心肌病病理生理过程中的多个环节。本文将主要阐述miRNAs与糖尿病心肌病的一些病理性改变(如心肌肥大、纤维化、细胞凋亡、代谢失调、心律失常)的关系及作用。
Diabetic cardiomyopathy（ DCM） is characterized by myocardial structural remodeling and functional remodeling as a specific cardiomyopathy in people with diabetes,which is not dependent on coronary heart disease,hypertension and other heart diseases. It was found that a plenty of factors can affect diabetic cardiomyopathy,such as metabolic disorders,microvascular disease,calcium transport,autonomic neuropathy,etc,but its mechanism of pathogenesis is unclear. MicroRNAs（ MiRNAs）,is a small non- coding RNA molecule,which functions in RNA silencing and post- transcriptional regulation of gene expression. It was involved in regulating a variety of cardiovascular diseases,such as diabetic cardiomyopathy. This article will conclude role of miRNAs in the pathological changes of diabetic cardiomyopathy such as cardiac hypertrophy,fibrosis,apoptosis,metabolism disorders and cardiac arrhythmias.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第19期1977-1979,共3页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金资助项目(81100134)
哈尔滨医科大学药学院大学生创新创业训练计划基金资助项目(YXY20140140)
