摘要
目的：检测原发性高血压（Essential hypertension，EH）患者血浆中性粒细胞明胶酶相关脂质运载蛋白（neutrophil gelatinase －associated lipocalin，NGAL）和血清胱抑素 C（CysC）的浓度并探讨其临床意义。方法选取92例 EH 患者为 EH 组，另选取88例健康体检者作为健康对照组。对所有入选对象分别检测血浆 NGAL 和血清 CysC 的浓度及各项生化指标，各组间进行比较。结果EH 组血浆 NGAL 浓度为（149．22±11．52）μg／L，血清 CysC 的浓度为（0．92±0．03）mmol／L；健康对照组血浆 NGAL 浓度为（101．4±7.71）μg／L，血清 CysC 的浓度为（0．71±0．02）mmol／L。EH 组血浆 NGAL 浓度和血清 CysC 浓度均明显高于对照组（F ＝27．491，P ＜0．01；F ＝24．646，P ＜0．01）；且血浆 NGAL 浓度在 EH 1级、2级和3级间呈逐渐增高趋势。血浆NGAL 与血清 CysC 浓度呈正相关（r ＝0．48，P ＜0．01）。结论EH 患者血浆 NGAL 和血清 CysC 的水平明显升高，且与高血压的分级及由高血压引起的肾脏损伤程度密切相关，两者均可作为早期发现 EH 引起的肾功能损害的诊断指标。
Objective To explore the levels of neutrophil gelatinase -associated lipocalin（NGAL）and Ser-um cystatin C（CysC）in plasma in essential hypertension（EH）and to discuss their clinical significance.Methods 92 patients with essential hypertension were selected as EH group.At the same time,88 healthy subjects were selected as the healthy control group.The levels of plasma NGAL,serum CysC and some other biochemical markers were detected.The results were statistically processed.Results The level of Plasma NGAL in EH group was（149.22 ± 11.52）μg/L and the level of serum CysC in EH group was（0.92 ±0.03）mmol/L.The level of Plasma NGAL in the healthy control group was（101.4 ±7.71）μg/L and the level of serum CysC in the healthy control group was（0.71 ± 0.02）mmol/L.The levels of Plasma NGAL and serum CysC were significantly increased in EH group compared with those of the healthy control group（F =27.491,P 〈0.01;F =24.646,P 〈0.01）.Plasma NGAL was positively corre-lated with the degree of EH and the level of serum CysC（r =0.48,P 〈0.01）.Conclusion Plasma NGAL and serum CysC were significantly increased in EH patients,with a significant positive correlation to the degree of nephropathy damage.Both of them can become diagnostic measurements for early diagnosis of nephropathy damage induced by EH.
出处
《中国基层医药》
CAS
2015年第18期2754-2756,I0002,共4页
Chinese Journal of Primary Medicine and Pharmacy
基金
江苏省徐州市科技计划项目（XZZD1348）
