摘要
目的:探讨重组人脑利钠肽(rh BNP)对急性射血分数保留心力衰竭的临床治疗作用。方法:选择2008年6月至2014年6月间我院收治的20例急性射血分数保留心力衰竭患者为研究对象,其中10例予以硝普钠静脉注射48小时,10例予以rh BNP静脉注射48小时。48小时后,评估和比较两组患者心力衰竭的临床改善情况;72小时后,复查和比较两组患者血浆NT-pro BNP的下降值。结果:硝普钠组患者呼吸困难缓解积分(1.4±1.35)明显低于rh BNP组(3.5±0.71),rh BNP组呼吸困难缓解时间(3.68±1.69 h)显著短于硝普钠组(21.50±18.43 h),血浆NT-pro BNP浓度下降值(864.60±585.92 pg/ml)明显高于硝普钠组(423.30±284.06 pg/ml)。结论:rh BNP治疗急性射血分数保留心力衰竭的临床疗效优于硝普钠。
Objective： To research the clinical efficacy of rh BNP in the treatment of heart failure with preserved ejection fraction（HF-PEF）. Methods： 20 cases of patients admitted in hospital due to HF-PEF from june 2008 to june 2014 were enrolled in the research.10 patients received Sodium Nitroprusside threpy for 48 h, and the others received rh BNP instead. 48 h later, the clinical improvements of heart function were assessed and compared between two groups; 72 h later, the plasma concentration of NT-pro BNP were rechecked and compared between two groups. Results： The dyspnea remission integral of sodium nitroprusside group（1.4±1.35） was significantly lower than that of the rh BNP group（3.5±0.71, P〈0.05）, the dyspnea remission time of rh BNP group（3.68±1.69 h） was much shorter than that of the sodium nitroprusside group（21.50±18.43 h, P〈0.05）, the decreased plasma NT-pro BNP concentration of rh BNP group（864.60±585.92 pg/ml） was obviously higher than that of sodium nitroprusside group（423.30±284.06 pg/ml, P〈0.05）. Conclusion： The clinical efficacy of rh BNP was superior to sodium nitroprusside in the treatment of HF-PEF.
出处
《现代生物医学进展》
CAS
2015年第25期4899-4901,共3页
Progress in Modern Biomedicine
基金
黑龙江省自然科学基金项目(H201428H0212)
关键词
重组人脑利钠肽
急性射血分数保留心力衰竭
治疗
Recombinant Human Brain Natriuretic Peptide
Acute Preserved Ejective Function heart failure
Treatment
