摘要
目的：探讨参麦注射液对膝关节置换术全麻患者认知功能的影响。方法：选取2012年1月—2015年1月在膝关节置换术的80例患者为研究对象，随机分为两组，每组40例。手术前两组患者均未用药。对照组：手术切皮后，输注生理盐水。观察组：手术切皮后，静脉输注参麦注射液。结果：两组患者各时间点平均动脉压、心率及血氧饱和度比较，差异均无统计学意义（P〉0．05）。观察组术后意识恢复时间（9．8±2．2）min少于对照组术后意识恢复时间（15．2±3．7）min，差异具有统计学意义（P〈0．01）。术后第3天及术后第7天，两组患者空腹血糖水平和肝肾功能指标比较，差异均无统计学意义（P〉0．05）。术后第3天、7天，观察组术后认知功能评分均高于对照组，差异具有统计学意义（P〈0．01-0．05）。术后3d，观察组术后认知功能障碍发生率12，5％低于对照组术后认知功能障碍发生率20．0％，差异有统计学意义（P〈0．05）。术后7d，观察组术后认知功能障碍发生率7．5％低于对照组术后认知功能障碍发生率15．0％，差异有统计学意义（P〈0．05）。结论：参麦注射液不仅能够提高膝关节置换术患者全麻术后认知功能，缩短术后意识恢复时间，而且可降低认知功能障碍的发生率。
Objective： To investigate the effect of Shenmai Injection on cognitive function in patients undergoing intervention in the knee joint replacement operation. Method： A total of 80 patients with knee joint replacement operation from 2012 January to 2015 January in our hospital were as the research object and were randomly divided into two groups, each group 40 cases. Before operation, two patients had no medication. Control group：operation after skin incision, infusion of normal saline. Observation group ： operation after skin incision, intravenous injection of Shenmai injection. Results ： Mean arterial pressure, heart rate, blood oxygen saturation at each time point between the two groups were not significant （ P 〉 0.05）. After the operation, the consciousness recovery time （9.8 ±2.2 ）min in the observation group was less than （ 15.2 ± 3.7 ） min of the control group and the difference was statistically significant （ P 〈 0.01 ）. 3 d and 7 d after operation, two groups＇ fasting blood glucose levels and liver function indicators had no significant differences （ P 〉 0.05）. The score of cognitive function after operation in the observation group was higher than those in the control group and there was statistically significant difference （ P 〈 0. 01 ,P 〈 0.05 ）. 3 d after operation, the incidence of cognitive dysfunction in the observation group was 12.5% ,lower than 20% of the control group and the difference was statistically significant （P 〈 0. 05 ）. 7 d after operation, the incidence of cognitive dysfunction after operation in the observation group was 7.5% ,lower than 15% in the control group and the difference was statistically significant （ P 〈 0. 05）. Conclusion： Shenmai Injection can not only improve the cognitive function of patients with general anesthesia in total knee arthroplasty operation after the operation and shorten the time of consciousness recovery after the operation, but also reduce the incidence of cognitive dysfunction.
出处
《中华中医药学刊》
CAS
北大核心
2015年第10期2403-2406,共4页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省自然科学基金项目(LY14H060001)
关键词
参麦注射液
膝关节置换术
全身麻醉
认知功能
Shenmai Injection
total knee arthroplasty
general anesthesia
cognitive function
