摘要
目的：分析血尿酸（ UA）、尿微量白蛋白水平与2型糖尿病颈动脉内膜病变的关系。方法选取2012年4月至2014年4月于周口市人民医院接受治疗的80例2型糖尿病患者作为研究对象,分别检测其血尿酸及尿微量白蛋白水平。按照尿微量白蛋白排泄率（ UAER）将其分为低排泄率组（ A组,48例）高低排泄率组（ B组,32例）。同时根据患者的UA上升情况将其分为升高组（ C组,49例）与非升高组（ D组,31例）,分析患者颈动脉内膜病变与UA、尿微量白蛋白水平之间的相关性。结果 A组患者UA水平为（405.13±49.11）μmol/L,显著高于B组[（202.31±39.33）μmol/L,P〈0.05]；且 A 组 UAER、颈动脉内膜中层厚度（IMT）分别为（237.10±31.55）μg/min、（1.00±0.22）mm,均显著高于B组[（128.01±98.22）μg/min、（0.78±0.26） mm,P〈0.05]；C组UA、UAER、IMT分别为（389．18±51.11）μmol/L、（269.01±59.11）μg/min、（1.06±0.28）mm,也显著高于D组[（3213.23±31.55）μmol/L、（132.10±103.36）μg/min、（0.82±0.17）mm,P〈0．05]。分别将实验室指标作为自变量,以颈动脉IMT作为应变量,结果提示颈动脉IMT与UA、UAER均存在明显正相关联系（r=0.19998、0.2112,P〈0.05）。结论早期检测2型糖尿病患者血尿酸及尿微量白蛋白水平可为改善患者的预后提供指导,有较高的应用价值。
Objective To analyze the correlation of carotid artery internal membrane lesion in type 2 diabetes pa-tients with microalbuminuriaetion, uric acid （UA）. Methods Eighty patients with type 2 diabetes mellitus from April 2012 to April 2014 were divided into two groups based on uric albumin excretion ratio （ UAER ） with 48 cases with low UAER in group A and 32 cases with high UAER in group B. They were also divided into two groups based on the changes of uric acid with 49 cases with increased uric acid in group C and 31 cases with non-increased uric acid in group D. The correlation between uric acid, UAER and carotid artery internet media type（ IMT） were analyzed. Results The UA level of group A [（05. 13 ± 49. 11） μmol/L] was significantly higher than that of group B[（202. 31 ± 39. 33）μmol/L, P〈0. 05]. The UARE[（237. 10 ± 31. 55） μg/min] and IMT[（1. 00 ± 0. 22）mm] of group A were significantly higher than those of group B[（128. 01 ± 98. 22）μg/min,（0. 78 ± 0. 26） mm, P〈0. 05]. The UA[（389. 18 ± 51. 11）μmol/L], UAER[（269. 01 ± 59. 11）μg/min] and IMT[（1. 06 ± 0. 28）mm] of group C were significantly higher than those of group D[（3213. 23 ± 31. 55）μmol/L,（132. 10 ± 103. 36）μg/min,（0. 82 ± 0. 17） mm,P 〈0. 05]. Laboratory indexes were taken as argument and IMT were taken as dependent variable, it turned out that there was independent positive correlation of carotid artery IMT with UAER, UA in type 2 diabetes patients（r=0. 19998,0. 2112,P〈0. 05）. Conclusions To de-tect the uric acid and microalbuminuria of type 2 diabetes patients earlier can provide guidance for improving the prognosis, and has higher application value.
出处
《中国实用医刊》
2015年第20期45-46,共2页
Chinese Journal of Practical Medicine
关键词
血尿酸
尿微量白蛋白
2型糖尿病
颈动脉内膜病变
相关性
Uric acid
Microalbuminuria
Type 2 diabetes
Carotid artery internal membrane lesion
Correlation
