摘要
目的探讨高尿酸血症与老年2型糖尿病脑梗塞患者危险性的关系。方法46例老年2型糖尿病并发脑梗塞患者(观察组)及38例老年2型糖尿病非脑梗塞患者测量身高、体重及血压;采用全自动生化分析仪检测血尿酸、空腹及餐后2 h血糖、血清总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及载脂蛋白B(ApoB),采用放射免疫计数器检测空腹胰岛素。并对两组的血尿酸、血糖、血脂及血清胰岛素水平等进行比较。结果(1)观察组血尿酸、空腹及餐后2 h血糖、TC、TG、ApoB、空腹胰岛素、胰岛素抵抗指数、收缩压及舒张压均明显高于对照组(P<0.01,P<0.05),HDL-C明显低于对照组(P<0.01);(2)观察组高尿酸血症的发生率明显高于对照组(P<0.01)。结论高尿酸血症与高血糖、高血脂、高胰岛素血症、高血压是老年2型糖尿病合并脑梗塞的高危因素,应适时监测,积极干预。
Objective To explore the relationship between hyperuricemia and brain infarction in aged type 2 diabetes mellitus. Methods Clinical data including the hight, weight, blood pressure, uric acid, fasting blood glucose,postprandial 2 h blood glucose, fasting insulin, TC,TG, HDL-C,LDL-C and ApoB were collected and contrasted in 46 cases aged type 2 diabetes mellitus with brain infarction（study group） and 38 cases aged type 2 diabetes mellitus without brain infarction （control group）. Results Compared with controls group, uric acid, fasting and postprandial 2h blood glucose, cholesterol, triglyceride, apolipoprotein B, fasting insulin, HOMAIR, ststolic blood pressure and diastolic blood pressure increased obviously in study group （P〈 0. 01,P〈0. 05）. High density lipoprotein cholesterol were lower in study group than those in control group （P〈0.01）. The incidence of hyperuricemia in study group was more than that in control group （P〈0.01）. Conclusion Hyperuricemia, hyperglycemia, hyperlipidemia, hyperinsulinism and hypertension are all the high-risk factors in aged type 2 diabetes mellitus with brain infarction, which we should detect on-time and intervent actively.
出处
《江西医学院学报》
2006年第4期93-95,共3页
Acta Academiae Medicinae Jiangxi
