摘要
目的探讨影响冻融胚胎移植(frozen-thawed embryo transfer,FET)妊娠结局的相关因素。方法回顾性分析本中心132例冻融胚胎移植周期,其中1例取消移植外,将另外131例移植周期按照妊娠结局分为妊娠组和未妊娠组进行研究。结果 132周期共解冻胚胎290枚,存活280枚(96.55%),移植131周期,临床妊娠率为48.85%(64/131),胚胎着床率为30.00%。患者的基本资料之间无显著性差异,FET周期临床资料中,妊娠组患者的胚胎复苏率、完全存活率、冷冻前和复苏后的优胚率、继续发育胚胎比例及移植胚胎中含有致密化以上胚胎比例均显著高于未妊娠组(99.26%vs94.77%;92.65%vs 77.78%;94.12%vs 84.31%;91.11%vs 77.93%;68.89%vs 39.31%;40.74%vs 18.62%)。FET周期患者在新鲜取卵周期中,两组的Gn用量与天数、获卵数、受精率及新鲜周期胚胎移植失败率之间无显著性差异,但妊娠组的优胚率和冷冻胚胎数均显著高于未妊娠组(65.80%vs 55.72%;7.69 vs 5.03)。结论在冻融胚胎移植中,患者新鲜周期的胚胎质量。
Objective：To investigate the correlative factors affecting the pregnancy outcome of frozen-thawed embryos transfer（FET）. Methods：A total of 132 cycles,besides one case cancelled,were analyzed retrospectively according to the pregnancy outcome：pregnancy or not. Results：A total of 290 cryopreserved embryos were thawed in 132 cycles with 280 survival embryos（96.55%）. The clinical pregnancy rate and implantation rate in the 131 FET cycles were 48.85% and 29.89%,respectively. There were no differences in the basic information of patient. Howerer,the rates were significantly higher in pregnancy group compared with none pregnancy group,including survival embryo rate（99.26% vs 94.77%）,intact survival embryo rate（92.65% vs 77.78%）,good embryos before freeze rate（94.12% vs 84.31%）,good embryos after thawing rate（94.81% vs 86.21%）,continued development embryo rate（67.41% vs 40.00%）and compaction embryo rate（42.22% vs 19.31%）. In the fresh cycle of these FET patients,there were no significant differences in the Gn dosage,Gn days,the number of oocytes retrieved,fertilization rate,the failure rate of embryo tansfer in fresh cycle between two groups,but the good embryo rate and the number of frozen embryo in pregnancy group were significantly higher more than none pregnancy group（65.80% vs 55.72%;7.69 vs 5.03）. Conclusion：the pregnancy outcome in FET cycles were determined by the embryo quality in fresh cycle,the process of frozen-thawed embryo and embryo development after thawing.
出处
《中国优生与遗传杂志》
2015年第9期97-99,共3页
Chinese Journal of Birth Health & Heredity
基金
高原低氧对不同方式受孕小鼠妊娠结局及子代发育的影响(CLZ14JB08)
