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尼索地平控释贴剂在自发性高血压大鼠体内的药动学-药效学结合模型的建立 被引量:1

Study on the Pharmacokinetic-pharmacodynamic Model of Nisoldipine Controlled-release Patches in Spontaneously Hypertensive Rats
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摘要 目的:建立尼索地平控释贴剂(NCRP)在自发性高血压大鼠(SHR)体内的药动学-药效学(PK-PD)结合模型。方法:将SHR随机分为贴剂(NCRP)组和片剂(尼索地平片)组,每组6只,植入微透析探针,按尼索地平计每只给药5 mg。收集给药后36 h内的血浆微透析液,采用高效液相色谱法测定尼索地平血药浓度,Win Nonlin 5.3软件计算药动学参数,以心率和血压为药效学指标,进行PK-PD结合模型研究。结果:与尼索地平片比较,NCRP具有控释效果;NCRP药物效应与效应室浓度以Sigmoid-Emax模型拟合,心率和收缩压的PK-PD模型主要参数分别为Emax:(2.65±0.06)、(10.71±0.87),EC50:(83.65±35.25)、(1.29±0.26)ng/ml,γ:(0.83±0.91)、(1.2±0.35),Keo:(0.37±0.53)、(0.91±0.24)h-1。结论:成功建立了NCRP在SHR体内的PK-PD结合模型。 OBJECTIVE:To establish the pharmacokinetic-pharmacodynamic(PK-PD) model of Nisoldipine controlled-release patches(NCRP)in spontaneously hypertensive rats(SHR). METHODS:SHR were randomized into a patch(NCRP)group and a tablet(Nisoldipine tablets)group,with 6 rats in each group. The microdialysis probes were implanted in SHR. Each rat was given 5 mg nisoldipine. Plasma microdialysate was collected within 36 h after administration. HPLC was adopted to determine the plasma concentration of nisoldipine,and WinNonlin 5.3 was employed to calculate Pharmacokinetic parameters. With heart rate and blood pressure as pharmacodynamic indexes,PK-PD model study was conducted. RESULTS:Vs. nisoldipine tablets,NCRP has con-trolled release effect. The relationship between NCRP drug effect and effect-site concentration met the Sigmoid-Emax model. The main parameters of the PK-PD model for heart rate and systolic blood pressure were as follows as Emax of (2.65 ± 0.06) and (10.71 ± 0.87),EC50 of (83.65 ± 35.25) and (1.29 ± 0.26) ng/ml,γ of (0.83 ± 0.91) and (1.2 ± 0.35),Keo of (0.37 ± 0.53) and (0.91±0.24)h-1. CONCLUSIONS:PK-PD model of NCRP in SHR has been established successfully.
出处 《中国药房》 CAS 北大核心 2015年第28期3915-3917,共3页 China Pharmacy
基金 广东省医学科研基金(No.B2012063)
关键词 尼索地平 控释贴剂 微透析 自发性高血压大鼠 药动学-药效学结合模型 Nisoldipine Controlled-release patch Microdialysis Spontaneously hypertensive rat Pharmacokinetic-pharmaco-dynamic model
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