摘要
目的：探讨阿尔茨海默病（AD）和血管性痴呆（VD）患者血浆中血糖、血脂、尿酸和炎症因子等代谢指标的临床意义。方法对2013年1月至2015年2月在上海交通大学附属瑞金医院卢湾分院老年科门诊和住院部患者采用简易智能状态量表（MMSE）进行痴呆筛选，分组测定AD组27例、VD组32例和对照组30例患者的体质量指数（BMI）、收缩压（SBP）、舒张压（DBP）、尿酸（UA）、空腹血糖（FPG）、糖化血红蛋白（HbA1c）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、C？反应蛋白（CRP）、白细胞介素？6（IL-6）的水平。结果 AD组和VD组与对照组比较，SBP、FPG、HbA1c有显著升高，且差异有统计学意义（ P＜0.05）。UA水平低于对照组，但差异无统计学意义（ P＞0.05）；血浆TC、TG、LDL-C均明显升高（P＜0.05），HDL-C明显降低（P＜0.01），但AD组和VD组差异无统计学意义（P＞0.05）。CRP、IL-6水平较对照组明显升高（P＜0.05），且VD组较AD组升高更为明显（P＜0.05）。结论 AD和VD老年患者中存在血糖、血脂，尿酸代谢异常和炎症反应。调节血糖、血脂可能是有效防治老年期痴呆的措施之一。
ObjectiveTo investigate the clinical significances of blood glucose, blood lipids, uric acid （UA） and inflammatory factors between the patients with Alzheimer’s disease （AD） and vascular dementia （VD）.MethodsMini-Mental State Examination （MMSE） was used to survey the elderly in-patients and out-patients in the Luwan Branch of Ruijin Hospital from January 2013 to February 2015. Finally, 27 AD patients, 32 VD patients and 30 sex- and age-matched normal individuals were enrolled in this study. Their body mass index （BMI）, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, UA, fasting plasma glucose （FPG）, glycosylated hemoglobin （HbA1c）, total cholesterol （TC）, triglycerides （TG）, low-density lipoprotein cholesterol （LDL-C）, high-density lipoprotein cholesterol （HDL-C）, C-reactive protein （CRP） and interleukin-6 （IL-6） were measured.Results The SBP, FPG and HbA1c were markedly higher in the AD and VD patients than in the normal controls （P〈0.05）. The UA level was lower in AD and VD patients than in controls, but there was no significant difference. The AD and VD patients had significantly higher TC, TG and LDL-C levels （P〈0.05） and obviously lower HDL-C level （P〈0.01） than the normal individuals, but there was no significant difference between the AD and VD patients （P〉0.05）. Compared with normal controls, both AD and VD patients had markedly higher CRP and IL-6 levels （P〈0.05）, and more obvious in the latter group （P〈0.05）.Conclusion The elderly patients with AD and VD have abnormal metabolism of glucose and lipids and inflammatory reaction. Regulation of blood lipids and glucose may be one of the effective measures in the prevention and treatment of SD.
出处
《中华老年多器官疾病杂志》
2015年第8期616-619,共4页
Chinese Journal of Multiple Organ Diseases in the Elderly
