摘要
目的探讨槐杞黄颗粒治疗儿童过敏性紫癜性肾炎的临床疗效及对细胞因子的影响。方法选择医院收治的患儿40例,随机分为对照组和观察组,各20例。对照组患儿给予常规治疗,观察组患儿在对照组基础上加用槐杞黄颗粒。结果治疗后,观察组总有效率为95.00%,明显高于对照组的75.00%(P<0.05);两组患者治疗后细胞因子白细胞介素(IL)-4、IL-10及肿瘤坏死因子-α(TNF-α)表达水平均较治疗前显著下降(P<0.05),且观察组下降更明显(P<0.05);两组患儿的CD4+与CD8+表达水平均明显升高,且观察组升高更明显(P<0.05);观察组不良反应发生率为30.00%,与对照组的35.00%相当(P>0.05),其中激素不良反应、胃肠道不适及呼吸道感染发病率均无明显差异(P>0.05)。结论槐杞黄颗粒治疗儿童过敏性紫癜性肾炎能显著提高临床疗效,改善细胞因子水平和患儿的免疫功能,且不增加不良反应的发生率。
Objective To investigate the clinical efficacy of Huaiqihuang Granules in treating children allergic purpura nephritis and its influence on cytokines. Methods Totally 40 children patients with allergic purpura nephritis were randomly divided into the control group and the observation group,20 cases in each group. The control group was given conventional treatment,on this basis the observation group used Huaiqihuang Granules. Results After treatment,the total effective rate of the observation group was 95. 00%,which was obviously higher than 75. 00% of the control group（ P ﹤ 0. 05）;the IL-4,IL-10 and TNF-α expression levels in the two groups significantly decreased compared with before treatment（ P ﹤ 0. 05 ）,and the decrease in the observation group was more obvious （ P ﹤ 0. 05）;the CD4^＋ and CD8^＋ expression levels in the two groups obviously increased compared with before treatment（ P ﹤ 0. 05）, and the increase in the observation group was more obvious（ P ﹤ 0. 05）. The incidence rate of adverse reactions in the observation group was 30%,which was lower than 35. 00% of the control group but without significant difference（ P ﹥ 0. 05）,adverse reactions of hormone,gastrointestinal discomfort,and incidence of respiratory tract infection of the two groups had no statistical difference（ P ﹥ 0. 05） . Conclusion Huaiqihuang Granules for treating allergic purpura nephritis in children can significantly improve the clinical efficacy,im-prove the level of cytokines,with good safety and less adverse reactions.
出处
《中国药业》
CAS
2015年第18期47-49,共3页
China Pharmaceuticals
关键词
槐杞黄颗粒
儿童
过敏性紫癜性肾炎
临床疗效
细胞因子
Huaiqihuang Granules
children
allergic purpura nephritis
clinical efficacy
cytokines
