摘要
目的：探讨2型糖尿病伴非酒精性脂肪肝病（non-alcoholic fatty liver disease,NAFLD）对患者血尿酸水平的影响。方法：收集1651例住院2型糖尿病患者的临床资料,包括：既往史,如糖尿病病程、肝炎病史;人体学参数,如身高、体质量、腰围、臀围;生化指标,如血糖、糖化血红蛋白（glycosylated hemoglobin A1c,HbA1c）、血脂、相关肝酶、尿酸、尿素及肌酐等。应用彩色多普勒超声诊断脂肪肝。结果：2型糖尿病伴NAFLD者较不伴NAFLD者的血尿酸水平显著升高[（331.8±90.8）μmol/L比（280.4±86.7）μmol/L,P〈0.001],高尿酸血症检出率显著增加（21.3%比8.8%,P〈0.001）。二元logistic回归分析显示,NAFLD（OR=2.508,95%CI：1.403~4.486）及丙氨酸氨基转移酶（alanine aminotransferase,ALT;OR=5.396,95%CI：2.481~11.733）、γ-谷氨酰转移酶（gamma-glutamyltransferase,GGT;OR=2.715,95%CI：1.320~5.585）水平升高是2型糖尿病患者发生高尿酸血症的独立危险因素。结论：NAFLD是2型糖尿病患者发生高尿酸血症的独立危险因素;血清ALT、GGT水平升高也是2型糖尿病患者发生高尿酸血症的独立危险因素。
Objective： To explore the impact of concomitant non-alcoholic fatty liver disease （NAFLD） of type 2 diabetes （T2DM） on patients＇ serum uric acid. Methods：Clinical data of 1651 hospitalized patients with T2DM were collected,including the past medical history such as duration of diabetes and history of hepatitis, the morphological parameters such as height, weight, waistline and hipline, and the biochemical indexes such as blood glucose, glycosylated hemoglobin A1 c（HbA1 c）, serum lipids, liver enzymes, uric acid, urea and creatinine. NAFLD was diagnosed by color doppler ultrasonography. Results： The se- rum uric acid level was significantly higher in T2DM patients accompanied with NAFLD than those without NAFLD（331.8 ± 90. 8 vmol/L vs. 280. 4 ± 86. 7 μmol/L,P〈0. 001） ,while detection rate of hyperuricemia significantly increased （21.3% vs. 8. 8 %, P〈0. 001）. Binary logistic regression analysis showed that NAFLD（OR = 2. 508,95 %CI： 1. 403-4. 486）, as well as the increase of serum levels of alanine aminotransferase （ALT; OR = 5. 396, 95 % CI： 2. 481 11. 733） and gamma-glutamyltrans- ferase（GGT; OR= 2. 715, 95%CI： 1. 320-5. 585）, were independent risk factors of hyperuricemia for patients with T2DM. Conclusions： NAFLD is an independent risk factor of hyperuricemia for patients with T2DM. As markers of liver damage, the increase of serum levels of ALT and GGT is also an independent risk factor of hyperuricemiafor patients with T2DM.
出处
《中国临床医学》
2015年第4期531-535,共5页
Chinese Journal of Clinical Medicine
关键词
2型糖尿病
非酒精性脂肪肝
高尿酸血症
Type 2 diabetes
Non-alcoholic fatty liver disease
Hyperuricemia
