摘要
目的观察短效口服避孕药(OCs)与维生素E胶囊联合治疗子宫内膜异位症(EMS)的疗效及不良反应。方法选择2012年2月至2014年6月中国人民解放军第180医院妇科就诊的EMS患者56例,随机分为试验组和对照组,分别给予优思明联合维生素E和单纯优思明,治疗前及治疗后2、4、6月后使用视觉模拟量表(VAS)评分法对盆腔疼痛、痛经和性交痛进行评分,用药期间记录不良反应。结果试验组治疗后6个月盆腔疼痛、痛经、性交痛评分均较治疗前显著降低(t值分别7.23、12.01、8.89,均P<0.05),对照组治疗后6个月盆腔疼痛、痛经评分均较治疗前显著降低(t值分别为6.57、10.32,均P<0.05),对照组性交痛治疗前后比较差异无统计学意义(t=2.17,P>0.05)。盆腔疼痛组间比较差异有统计学意义(F=7.82,P<0.05),痛经和性交痛组间比较无明显差异(,值分别1.95、1.53,均P>0.05);两组不良反应发生率分别为48.28%和62.96%,组间比较差异无统计学意义(x^2=1.22,P=0.27)。结论抗氧化剂维生素E联合OCs减轻EMS的盆腔疼痛优于单纯OCs。
Objective To investigate the curative effect of short-acting oral contraceptives （OCs） combined with vitamin E capsules on endometriosis （EMS） and its adverse reactions.Methods From February 2012 to June 2014, 56 cases of EMS in gynecology department of the 180th Hospital of People＇s Liberation Army were randomly divided into test group and control group.The test group administered vitamin E combined with Yasmin, and the control group administered Yasmin only.Pelvic pain, dysmenorrhea and dyspareunia were evaluated before treatment and 2, 4 and 6 months after treatment by using visual analogue scale （VAS）.Adverse reactions were recorded during treatment.Results Six months after treatment, scores of pelvic pain, dysmenorrheal and dyspareunia in the test group were significantly lower than those before treatment （t value was 7.23, 12.01 and 8.89, respectively, all P〈0.05）.The scores of pelvic pain and dysmenorrhea in the control group were remarkably lower than those before treatment （t value was 6.57 and 10.32, respectively, both P〈0.05）, but no obvious change was found in dyspareunia （t=2.17, P〉0.05）.Pelvic pain was significantly different between groups （F=7.82, P〈0.05）, but there were no significant differences in dysmenorrhea and dyspareunia between two groups （F value was 1.95 and 1.53, respectively, both P 〉0.05）.Adverse reaction rates of two groups were 48.28% and 62.96%, respectively, and the difference was not significant （χ^2 =1.22,P=0.27）.Conclusion Antioxidant vitamin E combined with Ocs has better effect on relieving pelvic pain of EMS than Ocs alone.
出处
《中国妇幼健康研究》
2015年第4期868-869,888,共3页
Chinese Journal of Woman and Child Health Research
