摘要
目的:优化染料木素磺丁基醚-β-环糊精包合物的制备工艺,并对其性质进行考察。方法:用溶液搅拌法制备染料木素磺丁基醚-β-环糊精包合物,采用星点设计-效应面法确定最佳工艺条件。运用相溶解度法考察在不同温度条件下磺丁基醚-β-环糊精对染料木素的增溶作用。通过差示扫描量热法(DSC)、红外光谱法(IR)对包合物进行验证。结果:染料木素磺丁基醚-β-环糊精包合物的最佳工艺条件为:染料木素与磺丁基醚-β-环糊精的投料比为1∶5,反应温度为50℃,反应时间为3.5 h。结论:成功制备染料木素磺丁基醚-β-环糊精包合物,显著提高了染料木素的溶解度。
OBJECTIVE To optimize formulation of genistein-sulfobutyl ether-β-cyclodextrin inclusion complex（GE-SBE-β-CD）and investigate its properties.METHODS GE-SBE-β-CD was prepared by stirring method.Optimum procedures for preparation were selected by central composite design-response surface methodology.Solubilization of SBE-β-CD on genistein was investigated by phase solubility method at various temperatures.Inclusion complex was characterized by differential scanning calorimetry（DSC）and infrared spectrometry（IR）.RESULTS Optimal conditions for preparing GE-SBE-β-CD were characterized as follows：molar ratio of genistein to sulfobutyl ether-β-cyclodextrin,1∶5;reaction temperature,50 ℃;reaction time,3.5 h.CONCLUSION GE-SBE-β-CD is prepared successfully.Solubility of genistein is improved by sulfobutyl ether-β-cyclodextrin complexation obviously.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2015年第18期1646-1650,共5页
Chinese Journal of Hospital Pharmacy
基金
重庆市自然科学基金项目(编号:cstc2012jjA10021)资助
高等学校博士学科点专项科研基金(编号:20125503120003)
重庆市卫生局医学科研项目(编号:2013-2-060)
重庆医科大学大学生科学研究与创新实验项目资助(编号:201432
201244
201217)
重庆市教育委员会科学技术研究项目(编号:KJ120307)
