摘要
目的探析放化疗联合深部热疗治疗胸段食管癌的近期和远期效果,并评价其安全性。方法将本院2010年4月至2012年3月确诊并收治的86例胸段食管癌患者随机分为研究组和对照组,每组各43例。对照组患者采用放化疗联合治疗,研究组在对照组基础上应用深部热疗。对比两组患者近期疗效、远期疗效及治疗期间不良反应发生情况。结果研究组患者显效率为88.37%(38/43),显著高于对照组[65.12%(28/43)](P<0.05)。研究组患者治疗总有效率为100.00%(43/43),对照组为90.70%(39/43),两组比较差异无显著性(P>0.05)。两组均无失访病例。研究组患者生存率、局部复发率及癌灶扩散率分别为62.79%、25.58%、25.58%,对照组分别为51.16%、27.91%、32.56%,两组比较差异均无显著性(P>0.05)。两组患者骨髓抑制、放射性食管炎、放射性肺炎、放射性皮炎、恶心呕吐、肝肾功能损伤发生率比较差异均无显著性(P>0.05)。结论放化疗联合深部热疗可显著提高胸段食管癌近期临床疗效,且不会增加治疗本身所产生的不良反应,具有显著的临床应用价值,但对食管癌的远期疗效无明显提升作用。
Objective To explore the short-term and long-term therapeutic effect and evaluate the security of radiation therapy and chemotherapy combined with deep hyperthermia in the treatment of thoracic esophageal cancer. Method 86 patients with thoracic esophageal cancer diagnosed and treated in our hospital from April 2010 to March 2012 were randomly divided into research group and control group, 43 cases in each group. Control group were given chemotherapy combined with radiotherapy. On the basis of research group were given deep hyperthermia. The short-term and long-term therapeutic effect, adverse reactions were compared between the two groups. Result The efficiency rate of research group was 88.37%（38/43）, significantly higher than control group [65.11%（28/43）]（P〈0.05）. The total effective rate of research group was 100.00%（43/43）, control group was 90.70%（39/43）, the difference was not significant（P〈0.05）. There was no patient lost to follow up in both groups. The survival rate, local recurrence rate and diffusibility of cancer in research group were 62.79%, 25.58% and 25.58% respectively, while control group were 51.16%, 27.91% and 32.56% respectively, the differences were not significant between the two groups（P〉0.05）. There was no significant difference in the incidence of myelosuppression, radiation esophagitis, radiation pneumonitis, radiodermatitis, nausea and vomiting and hepatic and renal function damage between the two groups（P〉0.05）. Conclusion The chemoradiotherapy combined with the deep hyperthermia in the treatment of thoracic esophageal cancer can significantly improve the short-term clinical effect and not significantly increase the adverse reaction, with the obvious clinical value; but it has no significant improvement on the long-term effect.
出处
《中国医学前沿杂志（电子版）》
2015年第7期122-125,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
关键词
食管癌
放疗
化疗
深部热疗
Esophageal cancer
Radiation therapy
Chemotherapy
Deep hyperthermia
