摘要
目的:总结新型热灌注机及装置在卵巢癌术中行腹腔热灌注化疗的临床应用情况及安全性。方法:21例卵巢癌患者均在全身麻醉下行开腹卵巢癌减灭术,术中采用新型热灌注机及装置行腹腔热灌注化疗。灌注液为3500ml0.9%氯化钠液加顺铂,流量2000～2800ml/min,灌注时间60～90分钟。结果:所有患者均成功接受了腹腔热灌注化疗。17例有腹水患者,热灌注化疗前腹水肿瘤脱落细胞检查阳性,热灌注化疗后未见肿瘤细胞。入腹腔水温(42.30±0.25℃)与出腹腔水温(41.91±0.24℃)比较差异无统计学意义(P>0.05)。热灌注化疗后患者心率平均增快8/min左右,鼻温增高1.5℃左右(P<0.05);血压无明显变化(P>0.05)。无与热灌注相关的并发症发生,化疗药物毒副反应轻微。结论:应用新型热灌注机及装置在卵巢癌术中行腹腔热灌注化疗,可以满足热灌注化疗的基本要求,有利于保证热灌注化疗效果,对患者影响较小。
Objective：To summarize the clinical application and safety of intraperitoneal hyperthermic perfusion chemotherapy in the surgical treatment of ovarian cancer. Methods ：21 ovarian cancer patients were treated with intraperitoneal hyperthermic perfusion chemotherapy after the primary tumor cytoreductive surgery under general anesthesia. The treatment was performed with 3500 ml perfusate （ normal saline and chemotherapy drug） in flow 2000 to 2800 ml/min for 60 to 90 min. Results： All patients received intraperitoneal hyperthermic perfusion chemotherapy successfully. There were no tumor cells detectedin the 17 patients with ascites after perfusion chemotherapy, whose ascites tumor shedding cells were positive before treat- ment. There was no significant difference in the temperatures of the perfusate in the abdominal cavity（ 42.30 ± 0.25℃） and out of the abdominal cavity（41.91± 0.24℃） （ P 〉 0.05）. The heart rate of the patients increased 8/min commonly and the nasal temperature increased about 1.5℃ generally（ P 〈0.05）, when treated with the intraperitoneal hyperthermic perfusion chemotherapy, While the blood pressure did not change significantly（ P 〉0.05）. No discomfort and no complications occurred after the patients treated with intraperitoneal hyperthermic perfusion chemotherapy. Conclusions：The intraperitoneal perfusion extracorporeal circulatory system used in the present research reaches the basic requirements of intraperitoneal hyperthermic perfusion chemotherapy in clinical treatment, which maybe helpful to ensure the hyperthermia effects with less impact on patients.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2012年第10期834-837,共4页
Journal of Practical Obstetrics and Gynecology
关键词
腹腔热灌注化疗
卵巢癌减灭术
顺铂
卵巢癌
Intraperitoneal hyperthermicperfusion chemotherapy
Ovarian cancer cytoreductive surgery
Cisplatin ~Ovarian cancer
