摘要
目的:探讨胃癌术后早期腹腔持续温热灌注化疗的临床意义。方法:将1998-2001年收治的胃癌手术患者的随机分成术后早期腹腔持续温热灌注化疗组及对照组,治疗后随访3年,对比两组的治疗效果。结果:比较两组的局部复发率、远处转移率及3年生存率等指标,Ⅰ期胃癌无显著差异;Ⅱ期、Ⅲ期、Ⅳ期胃癌有显著差异。肿瘤未浸润至浆膜的胃癌无显著差异;浸润至浆膜的胃癌有显著差异。结论:Ⅱ期、Ⅲ期、Ⅳ期胃癌及肿瘤浸润至浆膜的胃癌术后早期腹腔持续温热灌注化疗可减少局部复发率和远处转移率,提高3年生存率。Ⅰ期及病变未浸润至浆膜的胃癌可不必常规行术后早期腹腔持续温热灌注化疗。
Objective:To evaluate the beneficial effect of early continuous hyperthermic peritoneal perfusion chemotherapy after operation in gastric cancer patients. Methods: 848 cases of gastric cancer from 1998 to 2001 were divided into two groups randomly. One group was received early continuous hyperthemic peritoneal perfusion chemotherapy, the other group was controlled. The recurrent rates, the distant metastasis rates and the three-year survival rates in these two groups were Compared. Results:There were no significant differences of the recurrent rates, the distant metastasis rates and the three-year survival rates in stage Ⅰ gastric cancer cases in both group. And there were significant differences of the indexes above in stage Ⅱ 、 Ⅲ and Ⅳ gastric cancer cases between two groups. Conclusion: Early continuous hyperthermic peritoneal perfusion chemotherapy after operation in gastric cancer can reduce the recurrent rates,the distant metastasis rates,and improve the three years survival rates in stageⅡ、Ⅲ and Ⅳ gastric cancer patients. But, it is not necessary as a routine treatment in stagelgastric cancer.
出处
《中国临床医学》
北大核心
2005年第1期88-90,共3页
Chinese Journal of Clinical Medicine
基金
福建省科技厅科研基金资助项目(97-X-171)
