摘要
目的评价香丹注射液作为冠心病心绞痛的常规治疗方案的有效性及安全性。方法计算机检索Pubmed、Medline,CNKI、VIP和Wang Fang数据库,查找有关香丹注射液治疗冠心病心绞痛的随机对照试验(Randomized Controlled Trials,RCTs),检索时限为2000年1月-2014年6月。同时手工检索相关期刊与会议论文。由2位评价员根据纳入与排除标准独立进行文献筛选、资料提取和质量评价后,采用Review Manager 5.2软件进行Meta分析。结果共纳入8个RCTs,包括患者748例。Meta分析结果显示:与对照组比较香丹注射液治疗冠心病心绞痛的疗效,差异有统计学意义(P<0.00),治疗过程中患者面色潮红、轻微头痛、头晕、皮疹等不良反应对病情没有影响。结论香丹注射液治疗冠心病心绞痛的有效性和安全性有一定优势。受限于纳入研究的数量和质量,尚不能对其疗效和安全性得出肯定性结论。继续开展高质量、大样本的随机对照试验非常必要。
Objective To evaluate the efficacy and safety of Xiangdan Injection treatment of Coronary heart disease and angina. Methods Electronically searched databases including WanFang database, CNKI, VIP medicine, Medline for the randomized controlled trials, find information about Xiangdan Injection treatment of Coronary heart disease and angina pectoris from January 2000 to January 2014. Chinese search terms for Xiangdan injection, angina pectoris. Two reviewers independently screened literature in accord ance with the inclusion and exclusion criteria, data extraction and quality assessment. Then using RevMan 5.9, software for system evaluation. Results A total of 8 RCTs involving 748 patients were included. Meta -analysis showed： Xiang Dan injection in the treatment of angina pectoris terms compared with the con- trol group, the difference was statistically significant effect （P 〈0.01）, during treatment facial flushing, mild headache, dizziness, skin rashes and other adverse reactions were found in patients, no effect on the disease. Conclusion The available evidence suggests that Xiang Dan injection treatment of angina pectoris efficacy and safety have certain advantages. Limited to the quantity and quality of the studies included, still can not draw firm conclusions on its efficacy and safety. Therefore, continue to carry out high-quality, large sample randomized controlled trials is necessary.
出处
《新疆医科大学学报》
CAS
2015年第10期1257-1260,共4页
Journal of Xinjiang Medical University
基金
新疆医科大学科研创新基金(XJC2013209)
