摘要
目的探讨小泛素样修饰蛋白特异性蛋白酶(SENP)在人脑胶质瘤中的表达变化及与临床病理分级相关性。方法选择神经外科手术切除的脑胶质瘤组织43例作为胶质瘤组,尸解来源的正常脑组织9例作为对照组;Western blot法检测胶质瘤组与对照组中SENP1、SENP2、SENP6蛋白表达变化,并分析SENP蛋白表达量与患者临床病理分级之间关系。结果胶质瘤组织中SENP1、SENP2、SENP6蛋白表达量[分别为(0.47±0.12)、(0.78±0.17)、(0.94±0.21)]均明显增加,与对照组[分别为(0.35±0.03)、(0.36±0.13)、(0.23±0.08)]比较,差异有统计学意义(均P<0.05);脑胶质瘤组织中SENP1、SENP2、SENP6蛋白表达量与患者临床病理分级呈正相关(r=0.82、0.83、0.91,均P<0.05)。结论胶质瘤组织中SENP蛋白表达明显升高,SENP蛋白表达量与胶质瘤发生发展密切相关。
Objective To explore the change in expressions of small ubiquitin-related modifier-specific proteases （SENP） proteins in glioma and its correlation to clinical histological subclassification. Methods We selected 43 cases of glioma surgical resection as glioma group and 9 cases of normal brain tissue obtained from autopsy sources as control group. The change in expressions of SENP1, SENP2, and SENP6 proteins was detected with Western blot and the rela- tionship between the expression of SENP proteins and histological subclassification of glioma was analyzed. Results The expressions of SENP1 （0.47± 0. 12 ）, SENP2 （0.78 ± 0. 17 ）, and SENP6 （0.94±0.21 ） proteins were significantly increased in glioma tissues compared to those of the control group （ 0. 35 ± 0.03,0.36 ± 0. 13, and 0.23 ± 0.08 ）, with statistically significant differences （all P 〈 0. 05 ） and the expression of SENP proteins was positively related to histological subclassification, with the correlation coefficients （r） of 0. 82,0. 83, and 0. 91 （ all P 〈 0. 05 ）. Conclusion The ex- pression of SENP proteins increases in glioma tissues and closely relates to the development of glioma.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2015年第9期1219-1221,共3页
Chinese Journal of Public Health
基金
国家自然科学基金(81201671)
吉林省科技厅资助项目(20140414049GH)
吉林医药学院科研启动项目(201101)
