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嘌呤P2受体的免疫调节功能 被引量:6

Immunoregulatory Effects of Purinergic P2 Receptors
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摘要 嘌呤P2受体(purinergic P2 receptors)是一类核酸及其衍生物受体,被激活后可调节免疫反应,如能够介导免疫细胞向炎症部位的迁移,影响免疫细胞的增殖、分化和凋亡以及影响其分泌的细胞因子和趋化因子来调节炎症。该文介绍了嘌呤P2受体的分类、在免疫细胞上的分布情况以及它们在调节免疫反应中的功能。 Purinergic P2 receptor is a kind of nucleic acid derivative receptor, it can regulate immune response when activated. The purinergic receptors play important roles in the modulation of proliferation, differentiation, apoptosis and migration of immune cells, as well as the secretion of cytokines and chemokines involved in inflammation. This article introduces the classification of the purinergic P2 receptors, the expression of purinergic P2 receptors on immune cells and their function in modulating immune response.
出处 《中国细胞生物学学报》 CAS CSCD 2015年第8期1151-1157,共7页 Chinese Journal of Cell Biology
基金 国家重点基础研究发展规划(973计划)(批准号:2014CB541903 2012CB910404) 国家自然科学基金面上项目(批准号:31171348 31371414) 上海市教委科研创新项目(批准号:14zz042) 新药研究国家重点实验室开放基金资助(批准号:SIMM1302KF-09) 中央高校基本科研业务费专项资金资助的课题~~
关键词 ATP 嘌呤P2受体 免疫 ATP purinergic P2 receptors immunology
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