摘要
目的探讨血清降钙素原与s TREM-1水平对多重耐药肺结核患有者早期临床疗效的相关性研究。方法连续性收录自2012年4月至2014年4月于我院就诊并被确诊为耐多药肺结核的患者160例。另纳入同期来院体检的志愿者60例。采用免疫荧光法检测血清PCT,酶联免疫吸附试验(ELISA)检测血清s TREM-1。并分析两种血清指标与耐多药肺结核的临床疗效与预后的相关性。结果在治疗前,肺结核患者血清PCT和s TREM-1水平明显高于对照组(0.19±0.08 ng/ml vs 0.03±0.01 ng/ml,181.32±34.2 ng/m L vs23.5±11.6 ng/m L)(P<0.05)。而有效组患者治疗前PCT和s TREM-1水平与无效组患者比较未见明显差异(P>0.05),经治疗后可见有效组患者在治疗后2个月和6个月两个时间点中血清PCT和s TREM-1水平明显低于无效组患者(P<0.05)。治疗后2个月时的血清PCT和s TREM-1水平具有较高的预后评价意义(AUC分别为0.82和0.86)。多因素COX分析可见白蛋白,PCT以及s TREM-1水平三者是独立的危险因素(P<0.05)。结论血清PCT和s TREM-1的水平与耐多药肺结核患者病情程度以及临床预后密切相关。
Objective To investigate the the correlation of serum PCT and sTREM-1 with clinical prognosis in patients with multi-drug resistant tuberculosis. Methods 160 patients with multi-drug resistant tuberculosis （MDR-TB） were enrolled in this study and were divided into two groups： the effective group and the ineffective group. 60 healthy people were taken as the control group. Serum concentration of PCT and sTREM-1 were detected by electrochemiluminescence immunoassay method and enzyme-linked immunosorbent assay, respectively. Results The concentration of PCT and sTREM-lin MDR-TB patients were significantly higher than those of healthy controls （0. 19 ± 0. 08 ng/ml vs 0. 03 ± 0. 01 ng/ml, 181.32 ± 34. 2 ng/mL vs 23.5± 11.6 ng/mL） （P 〈 0. 05 ）. There was no significant difference in the levels of PCT and sTREM-1 between the effective group and the ineffective group before treatment （P 〉 0.05 ）. The levels of PCT and sTREM-1 in the effective group were significantly lower than those in the ineffective group 2 and 6 months after the treatment （ P 〈 0.05 ）. ROC analysis showed that the levels of PCT and STREM-1 2 months after the treatment had the highest diagnostic value as AUC was 0.82 and 0.86 respectively. Multi-factor COX regression analysis showed that albumin, PCT and sTREM-1 were independent risk factors in MDR- TB patients （P 〈 0. 05 ）. Conclusion The serum contents of PCT and sTREM-1 are significantly related with the progression of disease in patients with MDR-TB.
出处
《临床肺科杂志》
2015年第10期1770-1773,共4页
Journal of Clinical Pulmonary Medicine
