摘要
目的探讨合并2型糖尿病的结直肠癌患者的临床特点及其潜在的临床意义。方法收集479例初次入院的结直肠癌患者的临床资料,根据有无合并2型糖尿病,将结直肠癌患者分为合并2型糖尿病的结直肠癌组(n=61)和无合并2型糖尿病的结直肠癌组(n=418),比较2组在年龄、性别、肿瘤浸润深度、癌胚抗原阳性率、凝血功能及5年生存率等方面的差异。结果合并2型糖尿病的结直肠癌组较无合并2型糖尿病的结直肠癌组年龄大,肿瘤T4比例更高,癌胚抗原阳性率更高,血浆凝血酶原时间及活化的部分凝血活酶时间更短,5年生存率更低(P﹤0.05)。结论合并2型糖尿病的结直肠癌患者发病年龄更年长,容易并发血栓性疾病,肿瘤浸润程度更深,预后更差。
Objective To investigate the clinical features and potential implications of colorectal cancer patients complicated with type 2 diabetes mellitus. Methods Clinical data of 479 patients diagnosed with colorectal cancer hospitalized were obtained. All patients were divided into the colorectal cancer with（ n =61） and without type 2 diabetes mellitus groups（ n = 418）. Age,gender,depth of tumor invasion,positive rate of carcinoembryonic antigen（ CEA）,coagulation function and 5-year survival rate were statistically compared between two groups. Results Compared with colorectal cancer patients without type 2 diabetes mellitus,those complicated with type 2 diabetes mellitus were older,had higher percentage of T4 staging tumor,higher CEA positive rate,shorter prothrombin time（ PT） and activated partial thromboplastin time（ APTT） and lower5-year survival rate（ all P〈0. 05）. Conclusions Colorectal cancer patients complicated with type 2 diabetes mellitus are older and apt to be complicated with thrombosis diseases. Besides,they have deeper tumor invasion and worse prognosis compared with their counterparts without type 2 diabetes mellitus.
出处
《新医学》
2015年第8期550-554,共5页
Journal of New Medicine
关键词
结直肠癌
糖尿病
临床特点
预后
Colorectal cancer
Diabetes mellitus
Clinical feature
Prognosis
