摘要
目的:评价甲胎蛋白(alpha-fetoprotein,AFP)联合高尔基体蛋白73(Golgi protein 73,G P73)检测对原发性肝癌诊断的价值,以期为临床医生提供参考.方法:检索Pub Med、EMbase、Medline、万方数据知识服务平台、CNKI、中国生物医学文献数据库等中外数据库2015-02之前发表的,关于AFP联合GP73检测对原发性肝癌诊断价值的研究,并对纳入文献的参考文献进行二次检索.严格按照纳入标准和排除标准选择文献、提取数据,并对纳入的文献行质量评价、异质性分析.采用Meta Disc1.4、Stata12.0软件进行Meta分析.结果:共纳入符合标准的文献19篇.AFP、G P 7 3单项检测对原发性肝癌诊断合并后的敏感度、特异度、曲线下面积(area under the curve,A U C)、Q指数分别为0.58(0.56-0.61)、0.84(0.83-0.86)、0.7642、0.7052和0.78(0.76-0.80)、0.97(0.86-0.88)、0.8848、0.8153.A F P联合G P73检测合并后的敏感度、特异度、AUC、Q指数分别为0.88(0.87-0.90)、0.82(0.80-0.83)、0.9461、0.8853.联合检测的A U C、Q指数明显高于AFP、GP73单项检测,Z检验提示差异有统计学意义(均P<0.05).结论:AFP联合GP73检测对原发性肝癌的诊断价值较高,对临床医生有一定的参考价值.
AIM：To perform a systematic review of the diagnostic value of Golgi protein 73（GP73）combined with alpha-fetoprotein（AFP） in primary hepatic carcinoma.METHODS：By searching PubMed,EMbase,Medline,Wanfang,CNKI and SinoMed databases from inception to February 2015,and manually searching the references of relevant papers,we retrieved both Chinese and English papers regarding combined detection of GP73 and AFP in primary hepatic carcinoma according to the inclusion and exclusion criteria.Then the quality and heterogeneity of the included studies were evaluated.Meta Disc1.4 and Stata12.0software were used to do the meta-analysis.RESULTS：Nineteen studies were included in our meta-analysis.The pooled sensitivity,specificity,the area under the curve（AUC） and Q index of AFP and GP73 alone were 0.58（0.56-0.61）,0.84（0.83-0.86）;0.7642,0.7052;0.78（0.76-0.80）,0.97（0.86-0.88）;and 0.8848,0.8153,respectively.The pooled sensitivity,specificity,AUC and Q index of combined AFP and GP73 were 0.88（0.87-0.90）,0.82（0.80-0.83）,0.9461,and 0.8853,respectively.The AUC and Q index of combined detection of GP73 and AFP were significantly higher than those of either alone（P 〈 0.05）.CONCLUSION：Combined detection of GP73 and AFP has high diagnostic value in primary hepatic carcinoma.
出处
《世界华人消化杂志》
CAS
2015年第22期3604-3613,共10页
World Chinese Journal of Digestology
