摘要
目的:比较空腹血糖(FPG)和口服葡萄糖后2小时血糖(2-h PG)两种检测方法,在门诊高血压患者合并糖代谢异常检出中的贡献。方法:为多中心横断面研究,2009年在全国22个省市46家医院中,依照统一入选标准连续入选门诊高血压患者至少100例,资料收集包括问卷调查、体格检查和血生化检测等。血糖检测包括FPG和2-h PG(除外有糖尿病史者)。共入选高血压患者5 206例,资料完整用于本次分析的4 942例。结果:1门诊高血压患者中53.0%合并有糖代谢异常,其中糖尿病患病率为24.3%。在1 202例糖尿病患者中,417例(34.7%)是新检出的患者。2新检出的417例糖尿病患者中,54.9%患者依据空腹血糖水平可以诊断,45.1%的患者仅是依据2-h PG水平诊断。在仅依据2-h PG水平新检出的糖尿病患者中,60.1%的患者空腹血糖水平<6.1mmol/L。3在新检出的1 417例糖尿病前期患者中,71.4%的患者仅是依据2-h PG水平诊断,其中68.9%的患者空腹血糖水平<5.6mmol/L。4与依据空腹血糖水平检出的糖尿病患者比较,依据2-h PG水平检出的糖尿病患者的年龄大、高血压病程长。结论:在门诊就诊的高血压患者中,50%以上的患者合并有糖代谢异常。在空腹血糖检测的基础上增加2-h PG检测,可提高糖代谢异常的检出率,尤其是老年患者。
Objective： To compare the contributions of fasting plasma glucose（ FPG） and 2-h post-load glucose（ 2-h PG） assays to detecting abnormal glucose regulation（ AGR） in hypertensive patients in China.Methods： A Multicenter cross-sectional study. Study patients were consecutively recruited from June to December 2009 from hypertension outpatient clinics in 46 hospitals in 22 provinces,autonomous regions,and municipalities in China. At least 100 consecutive patients were recruited in each hospital. FPG was measured for all patients and 2-h PG was measured in those without a history of diabetes mellitus（ DM）. A total of 4942 hypertensive outpatients aged≥20 years were included. Results： 1The prevalence of abnormal glucose regulation was53. 0% in hypertensive outpatients,and the prevalence of DM was 24. 3%. Of the 1 202 patients with DM,417（ 34. 7%） were newly diagnosed,and the proportion of newly detected DM was higher in the 〈45 years age group（ 52. 6%）. 2Of the 417 patients with newly diagnosed diabetes,45. 1% were identified using 2-h PG tests,and 60. 1%（ n = 113） of the patients had isolated increased 2-h PG levels but 5. 6mmol / L FPG levels.3Of the 1 417 patients with newly diagnosed prediabetes,71. 4% were identified by 2-h PG tests,and 68. 9%（ n = 698） Of the patients had isolated increased 2-h PG levels but 〈5. 6mmol/L FPG levels. 4Compared with patients diagnosed according to fasting glucose levels,diabetes patients diagnosed based on 2-h PG levels tended to be older and with longer duration of hypertension. Conclusion： Abnormal glucose regulation is common among hypertensive outpatients in China. Application of additional 2-h PG testing to FPG assay can improve the detection rate of AGR,especially in elderly patients.
出处
《心肺血管病杂志》
CAS
2015年第7期523-527,共5页
Journal of Cardiovascular and Pulmonary Diseases
关键词
高血压
糖代谢异常
口服葡萄糖糖耐量试验
Hypertension
Abnormal glucose regulation
Oral glucose tolerance test
