摘要
目的检测寻常型银屑病患者血清白介素-21(IL-21)、白介素-31(IL-31)水平,并探讨其与银屑病面积与严重性指数(PASI)评分之间的相关性。方法采用ELISA法检测25例寻常型银屑病患者(观察组)与25例健康人(对照组)的血清IL-21、IL-31水平,并进行比较。对寻常型银屑病患者血清IL-21及IL-31水平与其PASI评分进行相关性分析。结果观察组血清IL-21及IL-31水平均明显高于对照组(P<0.05);进展期组患者血清IL-21及IL-31水平明显高于稳定期组(P<0.05)。IL-21水平与PASI评分呈正相关(r=0.425,P=0.026);IL-31水平与PASI评分呈正相关(r=0.352,P=0.015)。结论寻常型银屑病患者血清IL-21、IL-31水平显著高于正常水平,且与疾病严重程度呈正相关,提示IL-21、IL-31可能在寻常型银屑病的发生发展中发挥重要作用。
Objective To detect the levels of serum intedeukin （IL）-21 and IL-31 in patients with psoriasis vulgaris, and to explore their relationship with psoriasis area and severity index （PASI）. Methods Enzyme linked immunosorbent assay （ELISA） was applied to detect the levels of serum IL-21 and IL-31 in 25 patients with psoriasis vulgaris （observation group） and 25 healthy people （control group） , and the results were compared. And the relationships between the levels of serum IL- 21 and IL-31 and PASI score in observation group were analyzed. Results Observation group was evidently higher in the levels of serum IL-21 and IL-31 than control group （P 〈0.05 ） , and progression group significantly higher than stable group （P 〈 0.05 ）. Both IL-21 and IL-31 were in positive association with PASI score （r = 0. 425, P = 0. 026 ; r = 0. 352, P = 0. 015）. Conclusion Serum IL-21 and IL-31 levels are higher in patients with psoriasis vulgaris than in normal people, and are in positive association with disease severity, suggesting that IL-21 and IL-31 may play an important role in the development and progression of psoriasis vulgaris.
出处
《实用临床医药杂志》
CAS
2015年第17期71-73,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11523004)
关键词
白介素-21
白介素-31
银屑病
PASI评分
interleukin-21
interleukin-31
psoriasis vulgaris
psoriasis area and severity index
