摘要
目的探讨幽门螺杆菌感染与胃癌HER2表达的相关性。方法选取2010年1月～2014年12月在我院诊断的168例胃癌患者纳入本研究，分析其临床特点和病理特征。使用免疫组织化学方法检测胃癌患者中HER2蛋白的表达，Hp检测方法采用Warthin—Stally（W—S）银染法染色。结果122例（72．6％）胃癌患者中幽门螺杆菌阳性，而18例（10．7％）患者HER2蛋白表达阳性。胃癌的不同病理类型中HER2蛋白表达率明显不同，管状腺癌中HER2蛋白表达率为12．8％（16／125），其他类型为4．7％（2／43）。HER2蛋白表达与幽门螺杆菌感染无相关性（P〉0．05）。结论胃癌患者幽门螺杆菌感染与HER2蛋白表达并无相关性，提示幽门螺杆菌导致胃癌的发病机制可能并不是通过影响HER2基因的活化，而是影响了其他致癌通路。
Objective To evaluate the correlation analysis of helicobacter pylori infection with HER2 protein expres- sion in gastric cancer tissue. Methods Clinical and pathological data of 168 patients with gastric carcinoma diagnosed in our hospital from January 2010 to December 2014 were enrolled in this study. The clinical characteristics and patho- logical feature were retrospectively analyzed. HER2 protein expression was examined by immunohistoehemieal staining, and the helieobaeter pylori infection was detected by Warthin-Stally staining. Results All 122 cases（72.6%） of patients with positive gastric cancer, and 18 eases（10.7%） with positive HER2 protein expression. HER2 protein expression rate in different pathological types of gastric cancer was significantly different. And the HER2 protein expression rate in tubular adenoearcinoma was 12.8%（16/125）, while that in other types was 4.7%（2/43）. There was no correlation between HER2 protein expression and Helicobacter pylori infection（P〉0.05）. Conclusion There is no correlation between helieobaeter pylori infection and HER2 expression expression in patients with gastric carcinoma, implying that the he- lieobaeter pylori may affect the other carcinogenic pathways rather than influence the HER2 gene activation.
出处
《中国现代医生》
2015年第24期14-16,共3页
China Modern Doctor
