摘要
目的通过检测血浆单核细胞趋化蛋白-1(MCP-1)/CC类趋化因子受体2(CCR2)炎性反应因子,探讨血管紧张素Ⅱ(AngⅡ)介导的炎性反应与高血压晨峰(MBPS)的相关性。方法将纳入研究的235例高血压患者根据是否存在MBPS(即血压晨峰超过30 mm Hg)分为晨峰组(121例)和非晨峰组(114例),比较2组患者的MCP-1/CCR2、血糖、血脂、体质量指数(BMI)以及24h动态血压水平。结果晨峰组MCP-1/CCR2明显升高,差异有统计学意义(P<0.05);2组患者上午的最高值血压差异无统计学意义(P>0.05),但夜间均值血压差异有统计学意义(P<0.05)。Pearson相关分析显示,MCP-1/CCR2分别与血压晨峰值高度相关(r=0.642,0.628;P<0.05)。结论 AngⅡ介导的炎性反应与MBPS可能存在密切的相关性,临床控制BMPS应有助于控制AngⅡ介导的炎性反应危害。
Objective To investigate the correlation between angiotension Ⅱ fAngⅡ ） mediated inflammatory reaction and morning blood pressure surge （MBPS） by detecting plasma MCP-1/CCR2 inflammatory factor. Methods 235 cases of hypertension patients were divided into the morning surge group （121 eases） and the non-morning surge group （114 cases） according to the presence of MBPS. The levels of MCP-1/CCR2, blood glucose,blood lipid,body mass index （BMI） and the 24 h ambulatory blood pressure were compared between two groups. Results The MCP- 1 and CCR2 levels were significantly increased in the morning peak group, and the difference between two groups was statistically significant（P〈0.05） ;There was no statistically significant differe/tce in the highest value of blood pres- sure during the forenoon in two groups（P〉0. 05） ,but the mean blood pressure at the night had statistical difference between two groups （P〈0.05）. The pearson correlation analysis showed that MCP-1 and CCR2 was highly correla- ted with MBPS respectively（r=0. 642,0. 628,P〈0.05）. Conclusion The close correlation may be exist between the Ang Ⅱ mediated inflammatory reaction with MBPS,the clinical control of BMPS should help to control the damage of Ang Ⅱ mediated inflammation reaction.
出处
《检验医学与临床》
CAS
2015年第16期2423-2424,2427,共3页
Laboratory Medicine and Clinic
