摘要
目的探讨血管内皮生长因子(VEGF)、可溶性血管内皮生长因子受体1(sFlt-1)和胰岛素生长因子-1(IGF-1)与妊娠高血压综合征(妊高征)母婴预后的关系。方法选取妊高征患者85例作为妊高征组,按照妊高征的严重程度分为妊娠高血压19例、子痫前期轻度36例和子痫前期重度30例。选择同期孕产期健康体检的孕妇30例和健康体检的妇女20例分别作为正常妊娠组和健康对照组。检测3组sFlt-1、VEGF、sFlt-1/VEGF和IGF-1水平,分析妊高征患者sFlt-1、VEGF、sFlt-1/VEGF和IGF-1水平与疾病严重程度和胎儿结局的关系。结果妊高征组和正常妊娠组的VEGF和IGF-1水平均明显低于健康对照组(P均<0.01),而妊高征组明显低于正常妊娠组(P<0.01),VEGF和IGF-1水平随着妊高征患者病情的加重而降低(P均<0.01);妊高征组和正常妊娠组的sFlt-1和sFlt-1/VEGF水平均明显高于健康对照组(P均<0.01),而妊高征组的水平明显高于正常妊娠组(P<0.01),sFlt-1和sFlt-1/VEGF水平随着妊高征患者病情的加重而升高(P<0.01)。妊高征患者的血清sFlt-1/VEGF水平与胎儿生长受限、胎儿窘迫、新生儿窒息和新生儿死亡的发生率呈正相关,血清IGF-1水平与胎儿生长受限、胎儿窘迫、新生儿窒息和新生儿死亡的发生率呈负相关。结论妊高征患者血清sFlt-1/VEGF水平明显升高,而IGF-1水平明显降低,并随着病情的加重升高或降低更为明显,二者参与妊娠高血压疾病的发生发展,与胎儿的预后有关。
Objective It is to observe the levels of vascular endothelial growth factor（ VEGF）,soluble vascular endothelial growth factor receptor 1（ sFlt- 1） and insulin-like growth factor- 1（ IGF- 1） in patients with pregnancy-induced hypertension and their impact on the outcome of fetus. Methods 85 patients with pregnancy-induced hypertension were observed as pregnancy-induced hypertension group,and were divided into 19 cases in pregnancy-induced hypertension,36 cases in mild preeclampsia and 30 cases in severe preeclampsia according to the severity of pregnancy-induced hypertension. 30 healthy pregnant women and 20 health women were selected as normal pregnancy group and healthy control group at the same period.The levels of sFlt- 1,VEGF,sFlt- 1 / VEGF and IGF- 1 were detected in the three groups,and their relationship with severity of the disease and fetal outcomes were analyzed. Results The levels of VEGF and IGF- 1 in pregnancy-induced hypertension group and normal pregnancy group were significantly lower than those in healthy control group（ P〈0. 01）,and the levels of those in pregnancy-induced hypertension group were significantly lower than those in normal pregnancy group（ P〈0. 01）,and the levels of VEGF and IGF- 1 in patients with pregnancy-induced hypertension decreased as the severity increased（ P〈0. 01）. The levels of sFlt- 1 and sFlt- 1 / VEGF in pregnancy-induced hypertension group and normal pregnancy group were significantly higher than those in healthy control group（ P〈0. 01）,and the levels of those in pregnancy-induced hypertension group significantly higher compared with normal pregnancy group（ P〈0. 01）,and the levels of sFlt- 1 and sFlt- 1 / VEGF in patients with pregnancy-induced hypertension increased as the severity of pregnancy-induced hypertension increased（ P〈0. 01）. There were positively correlated among sFlt- 1 / VEGF levels and fetal growth restriction,the incidence of fetal distress,neonatal asphyxia and neonatal mortality; at the same time,there
出处
《现代中西医结合杂志》
CAS
2015年第26期2880-2882,2934,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
血管内皮生长因子
可溶性血管内皮生长因子受体1
胰岛素生长因子-1
妊娠高血压综合征
vascular endothelial growth factor
soluble vascular endothelial growth factor receptor 1
insulin-like growth factor-1
pregnancy-induced hypertension
