摘要
目的:探讨布地奈德对支气管哮喘患者血清炎性因子及免疫功能的影响。方法:选取支气管哮喘患者98例,按照就诊顺序将其分为观察组和对照组两组,各49例。对照组采用常规治疗,观察组在对照组的基础上加用布地奈德雾化吸入治疗,对比两组患者治疗前后血清炎性因子和免疫功能指标的变化。结果:两组患者治疗后的血清白介素-6、8、17(IL-6、IL-8、IL-17)及肿瘤坏死因子-α(TNF-α)水平均较同组治疗前有显著降低(P<0.05),但观察组治疗后与对照组治疗后各指标相比较降低更为明显(P<0.05);观察组治疗后IgA、IgG、IgM、CD4+、CD8+和CD4+/CD8+均较同组治疗前有明显升高,且与对照组治疗后比较显著增加(P<0.05)。结论:布地奈德治疗支气管哮喘能够有效改善患者症状体征,降低血清炎性因子水平,提高患者机体免疫功能,值得临床推广和应用。
Objective： To explore the effects of budesonide on serum inflammatory factors and immune function in pa- tients with bronchial asthma. Methods： A total of 98 cases of bronchial asthma patients were randomly divided into the obser- vation group and the control group according to the order of treatment, each of 49 cases. Patients in control group were treated with conventional treatment. On the basis of this, patients in the observation group were treated with budesonide inhalation. The clinical symptoms and signs, serum level of inflammatory factors and immune function of two groups were observed before and after treatment. Results： After treatment, the serum IL-6, IL-8, IL-17, TNF- alpha levels of observation group were sig- nificantly lower than the control group, with significantly difference（P〈0. 05）. After treatment, IgA, IgG, IgM, CD4＋, CD8＋ , and CD4＋/CD8＋ levels were significantly higher than the control group, with significantly difference （P〈0.05）. Con- clusion： The effect of budesonide on bronchial asthma is good, can effectively improve the symptoms and signs, reduce serum inflammatory factor levels, enhance immune function in patients. It is worthy of promotion and application .
出处
《海南医学院学报》
CAS
2015年第8期1042-1044,共3页
Journal of Hainan Medical University
基金
新疆维吾尔自治区卫生厅青年科技人才专项科研基金(2007yo3)~~
关键词
布地奈德
支气管哮喘
炎性因子
免疫功能
Budesonide
Bronchial asthma
Inflammatory factors
Immune function
