摘要
目的研究溃疡性结肠炎（UC）患者食物不耐受状况，为指导UC患者饮食护理提供依据。方法选取2013年9月至2014年8月就诊于天津医科大学总医院UC患者47例，采取Southedand疾病活动指数（DAI）将UC患者分为缓解期组、轻度活动组和中重度活动组，采用酶联免疫吸附法（ELIsA）检测uc患者及健康对照血清中食物特异性IgG抗体，与相关临床指标行统计学分析。结果UC患者食物不耐受阳性率较高，达68．09％（32／47）；不耐受阳性率最高的食物依次为鸡蛋、小麦、牛奶。缓解期组、轻度活动组和中重度活动组的患者食物不耐受阳性率分别为9／16、11／18和12／13，组间比较差异有统计学意义X2=7．418，P〈0．05。有肠外表现组食物不耐受阳性率为11／13，显著高于无肠外表现组的55．88％（19／34），2组比较差异有统计学意义，X2=2．234，P〈0．05。性别、年龄、体质量指数、病变范围分组各组间食物不耐受阳性率比较差异均无统计学意义，P〉0．05。结论UC患者食物不耐受阳性率高于健康人群，食物不耐受的发生与UC疾病活动度和肠外表现存在相关性，对指导UC患者饮食护理具有重要意义。
Objective To investigate the status of food intolerance of patients with ulcerative colitis, （UC）, to provide the basis for directing UC patients diet related nursing. Methods Forty-seven UC patients were selected from September 2013 to August 2014 in General Hospital of Tianjin University. The Southerland Disease Activity Index （DAI） was used to divide the UC patients into remission, mild activity and moderate to severe activity groups. The food-specific IgG antibodies status were tested by enzyme-linked immunosorbent assay in UC patients and healthy people. Relevant clinical parameters were analyzed statistically. Results Food intolerance rate in UC patients was as high as 68.08%（32/47）; the food species： egg, wheat and milk ranked the most frequently intolerance food. The food intolerance rates in remission, mild activity and moderate to severe activity groups were 9/16, 11/18, 12/13, there were significantly different, x2=7.418, P〈O.05. Extraintestinal manifestation group had significantly higher food intolerance rate compareed to non extraintestinal manifestation group：11/13 vs. 55.88%（19/34）, X2=2.234,P〈0.05. No significant difference of food intolerance rate were showed among groups categorized according to sex, age, body mass index, site of lesion, P〉0.05. Conclusions UC patients show higher food intolerance rate than healthy people. UC disease activity and extraintestinal manifestations are correlated to food intolerance, which is of great significance to guide diet related nursing of UC patient.
出处
《中国实用护理杂志》
2015年第23期1785-1788,共4页
Chinese Journal of Practical Nursing
基金
黎介寿院士肠道屏障研究专项基金（LJS_201008）
关键词
结肠炎
溃疡性
食物不耐受
疾病活动度
肠外表现
Colitis, ulcerative
Food intolerance
Disease active index
Extraintestinalmanifestation
