摘要
目的:探讨年轻女性体外受精-胚胎移植(IVF-ET)长方案周期累积活产率的影响因素。方法:回顾性分析首次接受IVF长方案助孕治疗的1 147例年轻且卵巢储备功能良好的不孕女性的临床资料,按完成一次取卵周期是否获得最终活产胎儿分为活产组与未获活产组,采用多因素Logistic回归分析影响累积流产率的相关因素。结果:活产组患者的体质量指数(BMI)较未获活产组显著降低(P<0.05),而获卵数、正常受精率及可移植胚胎数显著增高(P<0.05)。Logistic回归分析显示BMI及可移植胚胎数是年轻且卵巢储备功能良好的不孕女性首次行IVF长方案周期获得累积活产的重要影响因素,BMI<24.2 kg/m2及可移植胚胎数≥5患者的妊娠结局较佳。结论:年轻且卵巢储备功能良好的女性首次IVF长方案周期中,BMI及可移植胚胎数与累积活产率显著相关,较低的BMI及适当多的可移植胚胎数可提高一次取卵周期的累积活产率。
Objective： To analyze the potential related factors of cumulative live birth rate with long protocol in in vitro fertilization and embryo transfer（IVF-ET）. Methods： A total of 1 147 cycles were divided into two groups： obtained cumulative live birth group（group A） and without obtained cumulative live birth group（group B）. The potential related factors of cumulative live birth were evaluated by Logistic regression analysis.Results： The average body mass index（BMI） of group A was much lower than that of group B（P〈0.05）, while oocyte number, fertilization rate and the number of transferable embryos in group A were significantly higher than those in group B（P〈0.05）. Logistic regression analysis showed that BMI and the number of transferable embryos were the two vital factors of cumulative live birth with long protocol treatment in young women. Furthermore,BMI24.2 kg/m2 and the number of transferable embryos 5 help young infertile women obtain better pregnancy outcomes. Conclusion： To young infertile women with normal ovarian reserve, BMI and the number of transferable embryos had a strong relationship with cumulative live birth in the first long treatment cycle. The decreased BMI and increased number of transferable embryo can improve the cumulative live birth rate according to one oocyte retrieval cycle.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2015年第8期550-555,共6页
Reproduction and Contraception
基金
郑州市科技创新团队项目
项目号:113PCXTD435
