摘要
目的探究妊娠期妇女阴道内环境的改变是否与妊娠期霉菌性阴道炎的发病有关。方法选取妇产科门诊2011年7月-2012年7月诊断的孕早期妇女166例(不包括已患有霉菌性阴道炎的患者),选取阴道内环境改变的2个重要指标阴道内pH值及乳杆菌的量来判断是否为阴道内环境改变,采用前瞻性研究的方法,通过检查其阴道内环境是否改变而分组,其中阴道内环境改变组96例,阴道内环境正常组70例;pH值≤4.0组67例,pH值>4.0组99例;乳杆菌减少组58例,乳杆菌正常组108例。计算每组霉菌性阴道炎的发病率。结果 pH值≤4.0者发病率为17.9%(12/67),pH值>4.0者的发病率为6.1%(6/99),两组差异有统计学意义(χ2=5.804,P=0.016);乳杆菌减少者发病率25.9%(15/58),乳杆菌正常者发病率2.8%(3/108),两组差异有统计学意义(χ2=20.800,P=0.000);阴道内环境改变者发病率16.7%(16/96),阴道内环境正常者发病率2.9%(2/70),两组差异有统计学意义(χ2=7.985,P=0.005)。在乳杆菌正常的妊娠期妇女中,pH值是否降低与霉菌性阴道炎的发病无关(χ2=0.000,P=1.000)。结论妊娠期阴道内环境改变(pH值降低及乳杆菌下降)与霉菌性阴道炎发病率相关,可针对此现象进行妊娠期霉菌性阴道炎的防治。
Objective To explore whether the vaginal environment changes of pregnant women were correlated with pathogenesis of fungal vaginitis. Methods We selected 166 women in their early pregnancy in the Obstetrics and Gynaecology Clinic between July 2011 and July 2012 as the study objects （excluding fungal vaginitis patients already confirmed）. Two important indicators of changes in pH and the amount of vaginal lactobacilli were chosen to determine changes in the vaginal environment. Using prospective study method, by checking changes in the vaginal environment, the objects were divided into two groups： 96 were in the changing environment group, and 70 were in the normal environment group. Sixty seven of them had a pH value lower or equal to 4.0, and 99 higher than 4.0. Fifty-eight of them had a reduced amount of lactobacillus, and 108 had a normal amount of lactobacillus. The rate of fungal vaginitis in each group was counted. Results The morbidity rate in patients whose pH value was lower than or equal to 4.0 was 17.9% （12/67）, while it was 6.1% （6/99） in patients with a pH value higher than 4.0, and the difference was significant （χ2=5.804, P=0.016）. The morbidity rate in patients with a reduced amount of lactobacillus was 25.9% （15/58）, and it was 2.8% （3/108） in patients with normal lactobacillus, and the difference was also significant （χ2=20.800, P=0.000）. The morbidity rate for patients with changing vaginal environment was 16.7% （16/96）, and for those with normal environment was 2.9% （2/70）, and the difference was significant （χ2=7.985, P=0.005）. In those with normal lactobacillus, the reduction of pH value was not correlated with the occurrence of fungal vaginitis （χ2=0.000, P=1.000）. Conclusion The vaginal environment changes during pregnancy （pH value decrease and Lactobacillus decrease） are associated with the incidence of fungal vaginitis, and it can he prevented and treated based on this phenomenon.
出处
《华西医学》
CAS
2014年第6期1086-1088,共3页
West China Medical Journal
