摘要
Wnt5a是一种分泌型糖蛋白,是高度保守的Wnts蛋白家族成员之一。在生物体内Wnts家族参与调控细胞命运、胚胎发育、细胞增殖、迁移和分化等重要过程。研究表明,Wnt5a的表达调控及其信号转导与炎症应答密切相关,提示Wnt5a及其信号通路在炎症性疾病的发生、发展中发挥着重要作用。本文从Wnt5a与炎症因子、炎症信号转导通路以及炎症疾病等方面进行阐述和展望,旨在为以Wnt5a为靶点进行炎症性疾病的防治提供理论依据。
Wnt5a belongs to the large WNT family of cysteine-rich secreted glycoproteins, which is involved in multiple signaling pathways that regulate a variety of cellular processes, including cell motility, proliferation differentiation and so on during development. The regulation and signaling transduction of Wnt5a have been reported to closely relate to inflammatory response, which indicates that Wnt5a plays a critical role in the occurrence and development of inflammatory diseases. In this review, we summarized data on Wnt5a and its signaling pathway, as well as their involvement in inflammatory response. Further comprehensive understanding of the function and relationship between Wnt5a and inflammatory response would help us to develop novel diagnostic and therapeutic strategies for prevention and treatment of inflammatory diseases.
出处
《生理学报》
CAS
CSCD
北大核心
2015年第4期437-445,共9页
Acta Physiologica Sinica
基金
supported by the National Natural Science Foundation of China(No 81000946
81270359
81173047 and 31371161)
the Postdoctoral foundation of Hunan Provincial Science and Technology Department(No.2011rs4016)
关键词
WNT5A
炎症
炎症因子
信号通路
Wnt5a
inflammation
inflammatory factors
signaling pathway
