摘要
目的:探讨隔药灸脐与匹维溴铵治疗脾虚型肠易激综合征的作用机理。方法:将脾虚型肠易激综合征患者24例随机分为脐疗组、匹维溴铵组各12例。对治疗前后2组患者尿样进行代谢组学处理,并比较2组之间的差异。结果:2组治疗前后尿液代谢谱中儿茶酚胺类神经递质变化明显,其中脐疗组变化较为显著的是氨基酸、组胺、5-羟色胺、胆汁酸、内源性大麻素代谢物,这些代谢物涉及到体内氨基酸代谢、神经递质代谢及内源性大麻素代谢等过程;匹维溴铵组除此之外主要涉及花生四烯酸的代谢。结论:脐疗可显著抑制肠易激综合征患者的内脏高敏性,改善肠道神经、免疫、内分泌网络失调状况,改善脾虚型肠易激综合征患者的生存质量;治疗前后2组患者尿样代谢产物谱存在潜在的生物标记物。
Objective： To discuss the mechanisms of umbilical moxibustion on herbs and pinaverium bromide tablets in treating irritable bowel syndrome （IBS） of spleen deficiency pattern. Methods： All 24 patients were randomized into umbilical therapy group and pinaverium bromide tablets group, 12 cases each group. The metabonomics of urine specimen of the patients in both groups were detected before and after treating, and the differences between both groups were compared. Results： The neurotransmitters such as catecholamines and others in metabolic spectrum changed notably in both groups before and after treating, compared with pinaverium bromide tablets group, the metabolites including amino acid, histamine, 5-hydroxytryptamine, acid bile and endocannabinoids changed greatly in umbilical therapy group, and they were related to the metabolism of amino acid, histamine and endocannabinoids; besides that, pinaverium bromide tablets could adjust the metabolism of arachidonic acid mainly. Conclusion： Umbilical therapy could significantly inhibit visceral hypersensitivity of IBS patients, improve the disorders of enteric nerve, immunology, and endocrinology as well as life quality of IBS patients; there are potential biomarkers in urinary metabolic spectrum in both groups before and after treating.
出处
《西部中医药》
2015年第7期1-4,共4页
Western Journal of Traditional Chinese Medicine
基金
国家自然科学基金面上项目(编号30973789)
关键词
肠易激综合征
脾虚型
代谢组学
隔药灸脐法
神阙
irritable bowel syndrome of spleen deficiency pattern
metabonomics
umbilical moxibustion on herbs
ShenQue （RN8）
