摘要
三氯化铁能够有效地催化吲哚取代γ-羟基内酰胺中羟基形成新的C-C键.反应可能是通过N-酰亚胺离子历程进行.该反应能够在短时间内形成高产率的γ-取代内酰胺,反应条件温和,稳定性好,可规模放大.
An efficient FeC13-catalyzed nucleophilic substitution reaction of Y-hydroxylactams with in- doles has been developed. The reaction proceeded through an intermediary N-acyliminium ion and provid- ed substituted Y-lactams in excellent yields and in a very short reaction time. Meanwhile, the reaction could be stably scaled up in the mild condition.
出处
《海南师范大学学报（自然科学版）》
CAS
2015年第2期167-171,共5页
Journal of Hainan Normal University（Natural Science）
基金
山西省高等学校科技创新项目(2015176)
关键词
FECL3
催化
亲核取代
C-C键形成
吲哚
FeC13
catalysis
nucleophilic substitution
carbon-carbon bond formation
indole
