摘要
目的观察缩短β受体阻滞剂加量周期对慢性心力衰竭患者心功能的影响。方法将116例慢性心力衰竭患者随机分为实验治疗组和常规治疗组。实验治疗组在常规治疗基础上缩短β受体阻滞剂加量周期。观察治疗12周后患者运动耐量及左室射血分数(LVEF)的变化。结果治疗后两组心功能均无加重,两组血浆脑钠素浓度均下降(P<0.05),且实验治疗组下降更明显(P<0.05);两组6 min步行试验距离均增加(P<0.05),且实验治疗组增加更明显(P<0.05)。治疗后两组LVEF均提高(P<0.05)。实验治疗组总有效率高于常规治疗组(P<0.05)。结论慢性心力衰竭患者缩短β受体阻滞剂加量周期,心功能无加重,且更有效改善心功能、改善预后。
Objective The study was to observe the influence of cardiac function by reducing beta blockers＇ periodic increment in patients with chronic heart failure. Methods A total of 116 subjects with chronic heart failure were enrolled, The patients were randomly divided into experimental treatment group and conventional treatment group. The beta blockers＇ periodic increment were reduced on the basis of conventional treatment in the treatment group, and then observed the change of exercise tolerance and left ventricular ejection fraction（LVEF） in the two groups after 12 weeks. Results The cardiac function was not aggravated in the two groups after treatment. The NT-proBNP concentration was decreased in the two groups （P〈0.05）, but the treatment group decreased more significantly （P〈0.05）. Both of the 6minutes walking test and LVEF were increased significantly in the two groups （P〈0.05）, but the treatment group increased more obviously （P〈0.05）. The total effective rate in experimental treatment group was higher than that of the conventional treatment group. Conclusion Shortening beta blockers periodic increment was not aggravating heart function, however improving the cardiac function and prognosis in patients with chronic heart failure
出处
《热带医学杂志》
CAS
2015年第7期917-919,共3页
Journal of Tropical Medicine
