摘要
目的对产自内蒙古阿拉善盟的百合科葱属植物沙葱的化学成分进行研究,为其在食品营养和药理活性方面的研究提供依据。方法采用大孔吸附树脂、Sephadex LH-20等柱色谱及制备型高效液相色谱法等手段对其化学成分进行分离、纯化,并结合化合物的理化性质与波谱学数据鉴定结构。结果从沙葱中分离鉴定了7个单体成分,分别为山柰酚-3-O-β-D-吡喃葡萄糖苷(1)、山柰酚-3-O-β-D-芸香糖苷(2)、山柰酚-3-O-β-D-吡喃葡萄糖基(1→4)-β-D-吡喃葡萄糖苷(3)、山柰酚-3-芸香糖苷-4'-吡喃葡萄糖苷(4)、山柰酚-3-O-芸香糖苷-7-O-葡萄糖醛酸苷(5)、山柰酚-3-O-β-D-吡喃葡萄糖基(1→4)[α-L-吡喃鼠李糖基(1→6)]-β-D-葡萄糖苷(6)、山柰酚-3-O-龙胆二糖苷-4'-O-β-D-吡喃葡萄糖苷(7)。结论化合物4、6、7为从葱属植物中首次分离得到,化合物1、2、3和5为首次从该植物中分离得到。
The purpose of our stady is to investigate the chemical constituents of Allium mongolicum Regel which belongs to Allium genus of the Liliaceae family from Alxa League, Inner Mongolia. The main constituents in it are reported as polysaccharide, flavonoids and saponins. Its extract shows antineoplastic, antioxidant, and immunoregulation activities. In the process of our study, through D101 macroreticular resin, Sephadex LH-20 column chromatorgraphy and preparative HPLC, seven compounds were isolated, and identified as kaempferol-3-O-β-D-glucopyranoside （ 1 ）, kaempferol-3-O-β-D-rutinoside （ 2 ）, kaempferol-3-O-β-D-glu- copyranosyl- （ 1 →4 ） -fl-D-glucopyranoside （ 3 ）, kaempferol-3-rutinoside-4 ＇-glucopyranoside （ 4 ）, kaempferol- 3-O-rutinoside-7-O-glucuronide （ 5 ）, kaemperol-3-O-fl-D-glucopyranosyl （ 1→ 4 ） [ ct-L-rhamanopyranosyl （ 1→6 ） ]-β-D-glucopyranoside （ 6 ）, kaempferol-3-O-gentiobioside-4＇-O-β-D-glucopyranoside （ 7 ）. Among them,compounds 4,6 ,and 7 were obtained from Allium genus firstly, and 1 -3,5 were obtained from the species for the first time.
出处
《中国药物化学杂志》
CAS
CSCD
2015年第4期298-302,共5页
Chinese Journal of Medicinal Chemistry
基金
新世纪优秀人才支持计划项目(NCET-12-1069)
天津市高等学校创新团队培养计划项目(TD12-5033)
关键词
沙葱
化学成分
结构鉴定
Allium mongolicum Regel
chemical constituents
structural identification
